Pemetrexed/Carboplatin/Bevacizumab followed by Maintenance Pemetrexed/Bevacizumab in Hispanic Patients with Non-Squamous Non-Small Cell Lung Cancer: Outcomes according to Thymidylate Synthase Expression.
Cardona AF,Rojas L,Wills B,Arrieta O,Carranza H,Vargas C,Otero J,Cuello M,Corrales L,Martín C,Ortiz C,Franco S,Rosell R
MA5-13512 was used in Immunohistochemistry to evaluate the efficacy and safety of pemetrexed, carboplatin and bevacizumab followed by maintenance therapy with pemetrexed and bevacizumab in chemotherapy-naive patients with stage IV non-squamous non-small cell lung cancer.
Mon Jul 24 00:00:00 EDT 2017
Impact of intratumoral expression levels of fluoropyrimidine-metabolizing enzymes on treatment outcomes of adjuvant S-1 therapy in gastric cancer.
Kim JY,Shin E,Kim JW,Lee HS,Lee DW,Kim SH,Lee JO,Kim YJ,Kim JH,Bang SM,Ahn SH,Park DJ,Lee JS,Lee JS,Kim HH,Lee KW
MA5-13512 was used in immunohistochemistry - paraffin section to identify biomarkers relevant to treatment outcomes in gastric cancer patients receiving adjuvant S-1 chemotherapy.
Tue Feb 09 00:00:00 EST 2016
Molecular profiling in gastric cancer: examining potential targets for chemotherapy.
Journal of surgical oncology
Miura JT,Johnston FM,Thomas J,George B,Eastwood D,Tsai S,Christians KK,Turaga KK,Gamblin TC
MA5-13512 was used in immunohistochemistry (paraffin) to use molecular profiling to assess expression of biomarkers of operable gastric adenocarcinoma being treated with epirubicin, cisplatin, and 5-fluorouracil.
Mon Sep 01 00:00:00 EDT 2014
Thymidylate synthase and folyl-polyglutamate synthase are not clinically useful markers of response to pemetrexed in patients with malignant pleural mesothelioma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Lustgarten DE,Deshpande C,Aggarwal C,Wang LC,Saloura V,Vachani A,Wang LP,Litzky L,Feldman M,Creaney J,Nowak AK,Langer C,Inghilleri S,Stella G,Albelda SM
MA5-13512 was used in immunohistochemistry to examine the use of thymidylate synthase and folylpolyglutamate synthase as biomarkers to predict the of outcome after pemetrexed in patients.
Mon Apr 01 00:00:00 EDT 2013
Translational repression of thymidylate synthase by targeting its mRNA.
Nucleic acids research
Garg D,Beribisky AV,Ponterini G,Ligabue A,Marverti G,Martello A,Costi MP,Sattler M,Wade RC
MA5-13512 was used in western blot to elucidate how Hoechst 33258 reduces thymidylate synthase
Mon Apr 01 00:00:00 EDT 2013
Excision repair cross complementation group 1 and thymidylate synthase expression in patients with mesothelioma.
Clinical lung cancer
Kao SC,Lee K,Klebe S,Henderson D,McCaughan B,Vardy J,Clarke S,van Zandwijk N
MA5-13512 was used in immunohistochemistry to study the prognostic value of ERCC1 and thymidylate synthase expression in malignant pleural mesothelioma
Fri Mar 01 00:00:00 EST 2013
Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines.
Investigational new drugs
Giudice S,Benassi L,Bertazzoni G,Veratti E,Morini D,Azzoni P,Costi MP,Venturelli A,Pirondi S,Seidenari S,Magnoni C
MA5-13512 was used in western blot to investigate the relationship between folate and apoptosis using melanoma cells.
Wed Aug 01 00:00:00 EDT 2012
Thymidylate synthase and thymidine phosphorylase as predictive markers of capecitabine monotherapy in patients with anthracycline- and taxane-pretreated metastatic breast cancer.
Cancer chemotherapy and pharmacology
Lee SJ,Choi YL,Park YH,Kim ST,Cho EY,Ahn JS,Im YH
MA513512 was used in immunohistochemistry - paraffin section to assess the use of thymidylate synthase and thymidine phosphorylase as biomarkers to predict clinical outcomes of capecitabine monotherapy in patients with anthracycline- and taxane-pretreated metastatic breast cancer
Thu Sep 01 00:00:00 EDT 2011
Bax predicts outcome in gastric cancer patients treated with 5-fluorouracil, leucovorin, and oxaliplatin palliative chemotherapy.
Digestive diseases and sciences
Jeong SH,Han JH,Kim JH,Ahn MS,Hwang YH,Lee HW,Kang SY,Park JS,Choi JH,Lee KJ,Sheen SS,Lim HY
MA5-13512 was used in immunohistochemistry to study the prognostic significance of Bax, ERCC1, and TS in advanced gastric cancer patients treated with FOLFOX palliative chemotherapy
Sat Jan 01 00:00:00 EST 2011
Thymidine synthase, thymidine phosphorylase, and excision repair cross-complementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as first-line treatment for patients with advanced oesophageal squamous cell carcinoma.
British journal of cancer
Lee S,Park YH,Kim KH,Cho EY,Ahn YC,Kim K,Shim YM,Ahn JS,Park K,Im YH
MA513512 was used in immunohistochemistry - paraffin section to study biomarkers for predicting the response to capecitabine and cisplatin combination chemotherapy in metastatic oesophageal squamous cell cancer
Tue Sep 07 00:00:00 EDT 2010
Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Righi L,Papotti MG,Ceppi P,Billè A,Bacillo E,Molinaro L,Ruffini E,Scagliotti GV,Selvaggi G
MA5-13512 was used in immunohistochemistry - paraffin section to investigate the prognostic effectiveness of thymidylate synthase in the chemotherapy of malignant pleural mesothelioma
Sat Mar 20 00:00:00 EDT 2010
Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy.
Kostopoulos I,Karavasilis V,Karina M,Bobos M,Xiros N,Pentheroudakis G,Kafiri G,Papakostas P,Vrettou E,Fountzilas G
MA5-13512 was used in immunohistochemistry to study the association of Topoisomerase I with improved outcome in patients with resected colorectal cancer treated with irinotecan adjuvant chemotherapy
Thu Sep 24 00:00:00 EDT 2009
Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer.
British journal of cancer
Han SW,Oh DY,Im SA,Park SR,Lee KW,Song HS,Lee NS,Lee KH,Choi IS,Lee MH,Kim MA,Kim WH,Bang YJ,Kim TY
MA5-13512 was used in immunohistochemistry to study the efficacy of combined cetuximab and modified FOLFOX6 treatment in a phase II gastric cancer trial
Tue Jan 27 00:00:00 EST 2009
Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases.
Acta oncologica (Stockholm, Sweden)
Bendardaf R,Lamlum H,Ristamäki R,Korkeila E,Syrjänen K,Pyrhönen S
MA5-13512 was used in immunohistochemistry - paraffin section to evaluate thymidylate synthase and microsatellite instability in colorectal cancer
Mon Nov 17 00:00:00 EST 2008
Thymidylate synthase in situ protein expression and survival in stage I nonsmall-cell lung cancer.
Zheng Z,Li X,Schell MJ,Chen T,Boulware D,Robinson L,Sommers E,Bepler G
MA5-13512 was used in immunohistochemistry to examine the prognostic significance of thymidylate synthase in stage I nonsmall-cell lung cancer
Sun Jun 15 00:00:00 EDT 2008
Chemotherapeutic drugs may be used to enhance the killing efficacy of human tumor antigen peptide-specific CTLs.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Correale P,Del Vecchio MT,La Placa M,Montagnani F,Di Genova G,Savellini GG,Terrosi C,Mannucci S,Giorgi G,Francini G,Cusi MG
MA5-13512 was used in immunohistochemistry to investigate the influence of chemotherapy on the function of specific cytotoxic T lymphocytes
Thu Jun 12 00:00:00 EDT 2008
Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker.
Keam B,Im SA,Han SW,Ham HS,Kim MA,Oh DY,Lee SH,Kim JH,Kim DW,Kim TY,Heo DS,Kim WH,Bang YJ
MA5-13512 was used in western blot to report on a phase II clinical trial of modified FOLFOX-6 chemotherapy in advanced gastric cancer
Tue May 27 00:00:00 EDT 2008
Pemetrexed, a multitargeted antifolate drug, demonstrates lower efficacy in comparison to methotrexate against osteosarcoma cell lines.
Pediatric blood & cancer
Bodmer N,Walters DK,Fuchs B
MA5-13512 was used in western blot to investigate the efficacy of pemetrexed as a multitargeted antifolate drug against osteosarcoma cell lines
Tue Apr 01 00:00:00 EDT 2008
Adjuvant chemotherapy in completely resected gastric cancer: a randomized phase III trial conducted by GOIRC.
Journal of the National Cancer Institute
Di Costanzo F,Gasperoni S,Manzione L,Bisagni G,Labianca R,Bravi S,Cortesi E,Carlini P,Bracci R,Tomao S,Messerini L,Arcangeli A,Torri V,Bilancia D,Floriani I,Tonato M,Dinota A,Strafiuso G,Corgna E,Porrozzi S,Boni C,Rondini E,Giunta A,Monzio Compagnoni B,Biagioni F,Cesari M,Fornarini G,Nelli F,Carboni M,Cognetti F,Enzo MR,Piga A,Romiti A,Olivetti A,Masoni L,De Stefanis M,Dalla Mola A,Camera S,Recchia F,De Filippis S,Scipioni L,Zironi S,Luppi G,Italia M,Banducci S,Pisani Leretti A,Massidda B,Ionta MT,Nicolosi A,Canaletti R,Biscottini B,Grigniani F,Di Costanzo F,Rovei R,Croce E,Carroccio R,Gilli G,Cavalli C,Olgiati A,Pandolfi U,Rossetti R,Natalini G,Foa P,Oldani S,Bruno L,Cascinu S,Catalano G,Catalano V,Lungarotti F,Farris A,Sarobba MG,Trignano M,Muscogiuri A,Francavilla F,Figoli F,Leoni M,Papiani G,Orselli G,Antimi M,Bellini V,Cabassi A,Contu A,Pazzola A,Frignano M,Lastraioli E,Saggese M,Bianchini D,Antonuzzo L,Mela M,Camisa R
MA5-13512 was used in immunohistochemistry - paraffin section to discuss the results and consequences of surgical resection of gastric cancer
Wed Mar 19 00:00:00 EDT 2008
ERCC1 predicting chemoradiation resistance and poor outcome in oesophageal cancer.
European journal of cancer (Oxford, England : 1990)
Kim MK,Cho KJ,Kwon GY,Park SI,Kim YH,Kim JH,Song HY,Shin JH,Jung HY,Lee GH,Choi KD,Kim SB
MA5-13512 was used in immunohistochemistry - paraffin section to study the value of ERCC1 expression in predicting chemoradiation resistance and poor outcome in oesophageal cancer
Tue Jan 01 00:00:00 EST 2008
Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM).
Journal of neuro-oncology
Grunda JM,Nabors LB,Palmer CA,Chhieng DC,Steg A,Mikkelsen T,Diasio RB,Zhang K,Allison D,Grizzle WE,Wang W,Gillespie GY,Johnson MR
MA5-13512 was used in immunohistochemistry to study the prognostic value of thymidylate synthetase, ubiquitin specific protease 10 and survivin in glioblastoma multiforme
Fri Dec 01 00:00:00 EST 2006
5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine.
Journal of the National Cancer Institute
Correale P,Del Vecchio MT,Di Genova G,Savellini GG,La Placa M,Terrosi C,Vestri M,Urso R,Lemonnier F,Aquino A,Bonmassar E,Giorgi G,Francini G,Cusi MG
MA5-13512 was used in immunohistochemistry to evaluate a thymidylate synthase-directed polyepitopic peptide vaccine against tumors
Wed Oct 05 00:00:00 EDT 2005
Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy.
Shebzukhov YV,Koroleva EP,Khlgatian SV,Lagarkova MA,Meshcheryakov AA,Lichinitser MR,Karbach J,Jager E,Kuprash DV,Nedospasov SA
MA5-13512 was used in western blot to evaluate autoantibodies against thymidylate synthase as a biomarker for cancer progression and therapeutic effectiveness
Mon Aug 15 00:00:00 EDT 2005
High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ricciardiello L,Ceccarelli C,Angiolini G,Pariali M,Chieco P,Paterini P,Biasco G,Martinelli GN,Roda E,Bazzoli F
MA5-13512 was used in immunohistochemistry - paraffin section to study the role of high thymidylate synthase expression in colorectal cancer with microsatellite instability
Wed Jun 01 00:00:00 EDT 2005
Mechanism of 5-fluorouracil required resistance in human hepatocellular carcinoma cell line Bel(7402).
World journal of gastroenterology
Jin J,Huang M,Wei HL,Liu GT
MA5-13512 was used in immunocytochemistry to investigate the effect of fluorouracil on the expression of thymidylate synthase and MRP
Sun Dec 01 00:00:00 EST 2002
Role of biological markers in the clinical outcome of colon cancer.
British journal of cancer
Nanni O,Volpi A,Frassineti GL,De Paola F,Granato AM,Dubini A,Zoli W,Scarpi E,Turci D,Oliverio G,Gambi A,Amadori D
MA5-13512 was used in immunohistochemistry to study the prognostic markers for colon cancer
Mon Oct 07 00:00:00 EDT 2002
The anticytomegaloviral activity of raltitrexed is abrogated in quiescent mouse fibroblasts that overexpress thymidylate synthase.
Gribaudo G,Riera L,Lembo D,De Andrea M,Johnson LF,Landolfo S
MA5-13512 was used in western blot to investigate the effect of thymidylate synthase on the anticytomegaloviral activity of raltitrexed
Mon Jan 01 00:00:00 EST 2001