Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: HeLa, HepG2, HCT116, mouse brain.
Predicted reactivity: Mouse (88%), Chicken (87%), Bovine (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HECT-type ubiquitin transferase E3C; HectH2; Homologous to E6AP carboxyl terminus homologous protein 2; RAUL; RTA-associated ubiquitin ligase; ubiquitin-protein isopeptide ligase (E3); Ubiquitin-protein ligase E3C
Gene Aliases: AI853514; HECTH2; KIAA0010; KIAA10; mKIAA0010; UBE3C
UniProt ID: (Human) Q15386, (Mouse) Q80U95
Entrez Gene ID: (Human) 9690, (Mouse) 100763
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