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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 114 and 387 of Human UBE3C|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-31350 targets UBE3C in Immunofluorescence, Immunocytochemistry and Western Blot applications and shows reactivity with Human and mouse samples.
The PA5-31350 immunogen is recombinant fragment corresponding to a region within amino acids 114 and 387 of Human UBE3C.
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
HECTH2; ubiquitin-protein isopeptide ligase (E3); Ubiquitin-protein ligase E3C
AI853514; HECTH2; KIAA0010; KIAA10; mKIAA0010; UBE3C