Immunogen sequence: MAELTALESL IEMGFPRGRA EKALALTGNQ GIEAAMDWLM EHEDDPDVDE PLETPLGHIL GREPTSSEQG GLEGSGSAAG EGKPALSEEE RQEQTKRMLE LVAQKQRERE EREEREALER ERQRRRQGQE LSAARQRLQE DEMRRAAEER
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2B28; mY33K; Protein 2B28; SAKS1; SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; UBX domain-containing protein 1; UBXD10
Gene Aliases: 2B28; 4930455J02Rik; D19Ertd721e; RGD1309471; SAKS1; T25529; UBXD10; UBXN1