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Invitrogen
Uteroglobin Recombinant Rabbit Monoclonal Antibody (JU34-03)
Product Details
MA5-34625
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JU34-03
Immunogen
Synthetic peptide within Human SCGB1A1 aa 42-91
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2848533
Product Specific Information
Positive Control: A549, A431, HUVEC, mouse lung tissue lysate.
Target Information
Uteroglobin, which is a member of the Secretoglobin superfamily and is also known as Clara cell phospholipid-binding protein, is a multifunctional protein that can exert anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. The small, non-glycosylated protein named for its high levels of expression in pre-implantation embryos, where it exhibits growth stimulatory effects, is produced and secreted by the non-ciliated, non-mucous Clara cells predominant in the epithelial surfaces of pulmonary airways, as well as other non-ciliated epithelia. Members of the Secretoglobin superfamily demonstrate a high level of structural conservation and are characterized as small, secretory homo- or heterodimers. In addition to sequestering pro-inflammatory mediators and carcinogens, Uteroglobin has been implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: blastokinin; CC10; CCPBP; clara cell phospholipid-binding protein; clara cells 10 kDa secretory protein; Club cell phospholipid-binding protein; Club cells 10 kDa secretory protein; Secretoglobin family 1A member 1; secretoglobin, family 1A, member 1 (uteroglobin); UP-1; Urinary protein 1; urine protein 1; Uteroglobin
Gene Aliases: CC10; CC16; CCPBP; CCSP; SCGB1A1; UGB; UP-1; UP1
UniProt ID: (Human) P11684
Entrez Gene ID: (Human) 7356
Molecular Function:
cytokine
negative regulation of transcription from RNA polymerase II promoter
signal transduction
female pregnancy
embryo implantation
response to xenobiotic stimulus
response to ozone
response to lipopolysaccharide
negative regulation of interferon-gamma production
negative regulation of interleukin-13 production
negative regulation of interleukin-4 production
negative regulation of interleukin-5 production
response to silicon dioxide
response to cytokine
negative regulation of T cell proliferation
response to drug
negative regulation of catalytic activity
regulation of mRNA stability
regulation of inflammatory response
response to glucocorticoid
response to fibroblast growth factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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