|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Clone||KDR-2 or 260.4|
|Immunogen||Recombinant, extracellular, human VEGF receptor 2 protein fragment.|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay dependent|
|Flow Cytometry (Flow)||Assay dependent|
|Immunohistochemistry (IHC)||Assay dependent|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-20208 detects VEGF receptor 2 in human samples. This antibody does not detect VEGFR1, VEGFR3, or PDGF Receptor 1.
MA1-20208 has been successfully used in ELISA, FACS, immunohistochemistry and Western blot procedures.
The MA1-20208 immunogen is a recombinant, extracellular, human VEGF receptor 2 protein fragment.
Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGF Receptor 1 and VEGF Receptor 2 are both expressed in an endothelial cell-specific manner. They are detectable in virtually all tissues in adults and embryos. Monocytes express VEGF Receptor 1 and VEGF Receptor 2. VEGF Receptor 2 is involved in commitment of endothelial-cell lineages and to cell proliferation, while VEGF Receptor 1 seems to be responsible for guiding endothelial cells into the proper spatial organization of the lumen-containing vessels. VEGF Receptor 2 binds VEGF with high affinity but does not bind PIGF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.