This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA5-13835 targets XPA in IHC (P) and WB applications and shows reactivity with Human samples.
The MA5-13835 immunogen is recombinant human XPA protein.
The XPA (xeroderma pigmentosum group A) protein specifically recognizes the UV-or chemically damaged DNA lesions, and triggers the nucleotide excision repair process. XPA binds to the replication protein A (RPA) or the excision repair cross complementing 1 protein (ERCC1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a > 2000 fold increased risk to develop skin cancer at sun-exposed areas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA repair protein complementing XP-A cells; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; Xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A
Gene Aliases: XP1; XPA; XPAC
UniProt ID: (Human) P23025
Entrez Gene ID: (Human) 7507