Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
MA1-91470 detects alpha 1 Antitrypsin from human samples.
MA1-91470 has been successfully used in ELISA applications.
The MA1-91470 immunogen is full length native protein (purified) (Human)
Store at 4ºC short term. For extended storage, aliquot and store at -20ºC or below. Avoid freeze/thaw cycles.
Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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