MA5-15889 targets c-Jun in IF, IHC, and WB applications and shows reactivity with Human and mouse samples.
The MA5-15889 immunogen is purified recombinant fragment of human c-Jun expressed in E. Coli.
MA5-15889 detects c-Jun which has a predicted molecular weight of approximately 43kDa.
c-Jun is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activator protein 1; AH119; AP-1, AP1, c-Jun, Jun activation domain binding protein; AP1; enhancer-binding protein AP1; immediate early; Jun A; Jun activation domain binding protein; Jun oncogene; jun proto-oncogene; p39; Proto-oncogene c-Jun; Transcription factor AP-1; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
Gene Aliases: AP-1; AP1; c-Jun; JUN; Junc