This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Recommended positive controls: 293T, A431, Hela, HepG2, Mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (81%), Dog (98%), Pig (99%), Rabbit (99%), Rhesus Monkey (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CSBP; dC stretch-binding protein; dC-stretch binding protein; FLJ41122; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; RP11-575L7.1; Transformation up-regulated nuclear protein; transformation upregulated nuclear protein; TUNP
Gene Aliases: AUKS; CSBP; HNRNPK; HNRPK; KBBP; NOVA; TUNP
Molecular Function: RNA metabolism protein