Local and systemic inflammation triggers different outcomes of tumor growth related to infiltration of anti-tumor or pro-tumor macrophages.
Chinese medical journal
Liu X,Jiang Q,Shen S,Hou Y
12-5920-82 was used in Flow cytometry/Cell sorting to suggest that the different outcomes of tumor growth might be attributed to the infiltration of anti-tumor or pro-tumor immune cells, especially M1 or M2 type macrophages into tumor microenvironment.
Fri Aug 05 00:00:00 EDT 2022
Human skin dermis-derived fibroblasts are a kind of functional mesenchymal stromal cells: judgements from surface markers, biological characteristics, to therapeutic efficacy.
Cell & bioscience
Tai C,Xie Z,Li Y,Feng Y,Xie Y,Yang H,Wang L,Wang B
12-5920-82 was used in Flow cytometry/Cell sorting to show that human skin dermis-derived fibroblasts were a kind of functional MSCs with functionally equivalent therapeutic efficacy in treating specific complications, indicating fibroblasts potentially had the same lineage hierarchy of origin as MSCs and had a remarkable potential as an alternative to MSCs in the treatment of a variety of diseases.
Tue Jul 12 00:00:00 EDT 2022
Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages.
Cellular & molecular biology letters
Gao T,Huang F,Wang W,Xie Y,Wang B
12-5920-82 was used in Flow Cytometry to examine interleukin-10 (IL10) genetically modified clinical-grade MSCs (IL10-MSCs) and evaluate their clinical safety, effectiveness, and therapeutic mechanism in a completely transected SCI mouse model.
Thu Mar 17 00:00:00 EDT 2022
βig-h3-structured collagen alters macrophage phenotype and function in pancreatic cancer.
Bachy S,Wu Z,Gamradt P,Thierry K,Milani P,Chlasta J,Hennino A
12-5920-82 was used in Flow Cytometry to investigate the impact of thick collagen fibres on the phenotype and function of macrophages in pancreatic cancer.
Fri Feb 18 00:00:00 EST 2022
p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi.
Tan X,Banerjee P,Shi L,Xiao GY,Rodriguez BL,Grzeskowiak CL,Liu X,Yu J,Gibbons DL,Russell WK,Creighton CJ,Kurie JM
12-5920-82 was used in Flow Cytometry to show that p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi.
Tue Jun 01 00:00:00 EDT 2021
Reshaping the Immune Microenvironment by Oncolytic Herpes Simplex Virus in Murine Pancreatic Ductal Adenocarcinoma.
Molecular therapy : the journal of the American Society of Gene Therapy
Zhang L,Wang W,Wang R,Zhang N,Shang H,Bi Y,Chen D,Zhang C,Li L,Yin J,Zhang H,Cao Y
12-5920-82 was used in Flow Cytometry to suggest that oHSV reshapes the TME of PDAC (Pancreatic ductal adenocarcinoma) by boosting the immune activity and leads to improved responsiveness of PDAC to immunotherapy.
Wed Feb 03 00:00:00 EST 2021
Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis.
Journal of the American Society of Nephrology : JASN
Ruiz-Rosado JD,Robledo-Avila F,Cortado H,Rangel-Moreno J,Justice SS,Yang C,Spencer JD,Becknell B,Partida-Sanchez S
12-5920-82 was used in Flow Cytometry to reveal a previously unappreciated outcome for neutrophil-macrophage imbalance in promoting host susceptibility to acute pyelonephritis and the development of permanent renal damage.
Fri Jan 01 00:00:00 EST 2021
Lymphoid Tissue-Resident Alcaligenes Establish an Intracellular Symbiotic Environment by Creating a Unique Energy Shift in Dendritic Cells.
Frontiers in microbiology
Hosomi K,Shibata N,Shimoyama A,Uto T,Nagatake T,Tojima Y,Nishino T,Takeyama H,Fukase K,Kiyono H,Kunisawa J
12-5920 was used in Flow cytometry/Cell sorting to show an intracellular symbiotic system in which the LRC Alcaligenes creates a unique energy shift in DCs.
Wed Oct 28 00:00:00 EDT 2020
Anticancer Activity of Liquid Treated with Microwave Plasma-Generated Gas through Macrophage Activation.
Oxidative medicine and cellular longevity
Lee CB,Seo IH,Chae MW,Park JW,Choi EH,Uhm HS,Baik KY
12-5920-82 was used in Flow cytometry to determine that microwave plasma-generated gas-solution has the potential to convert the fate of macrophages, offering a treatment to control macrophage function in the tumour microenvironment.
Thu Sep 17 00:00:00 EDT 2020
IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.
Journal of immunology (Baltimore, Md. : 1950)
Sun L,Girnary M,Wang L,Jiao Y,Zeng E,Mercer K,Zhang J,Marchesan JT,Yu N,Moss K,Lei YL,Offenbacher S,Zhang S
12-5920 was used in Flow cytometry/Cell sorting to determine the effects of IL-10 on IL-17-mediated periodontitis-associated inflammatory networks.
Wed Apr 15 00:00:00 EDT 2020
Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge.
Brykczynska U,Geigges M,Wiedemann SJ,Dror E,Böni-Schnetzler M,Hess C,Donath MY,Paro R
12-5920 was used in Flow cytometry/Cell sorting to provide a resource for assessing the impact of nutrition and over-nutrition on the spectrum of macrophages across tissues with a potential for identification of systemic responses.
Tue Feb 04 00:00:00 EST 2020
Anti-Bacterial Effect of CpG-DNA Involves Enhancement of the Complement Systems.
International journal of molecular sciences
Kim TH,Park J,Kim D,Gautam A,Akauliya M,Kim J,Lee H,Park S,Lee Y,Kwon HJ
12-5920-82 was used in Flow Cytometry to suggest that CpG-DNA enhances the anti-bacterial activity of the immune system by augmenting the levels of complement systems after E. coli K1 infection and triggering other factors as well.
Wed Jul 10 00:00:00 EDT 2019
Heat-killed Mycobacterium tuberculosis prime-boost vaccination induces myeloid-derived suppressor cells with spleen dendritic cell-killing capability.
Ribechini E,Eckert I,Beilhack A,Du Plessis N,Walzl G,Schleicher U,Ritter U,Lutz MB
12-5920 was used in Flow cytometry/Cell sorting to demonstrate that Mtb booster vaccines induce M-MDSCs in the spleen that can be activated to kill DCs cautioning to thoroughly investigate MDSC formation in individuals after Mtb vaccination in clinical trials.
Tue Jun 04 00:00:00 EDT 2019
Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.
Kurelac I,Iommarini L,Vatrinet R,Amato LB,De Luise M,Leone G,Girolimetti G,Umesh Ganesh N,Bridgeman VL,Ombrato L,Columbaro M,Ragazzi M,Gibellini L,Sollazzo M,Feichtinger RG,Vidali S,Baldassarre M,Foriel S,Vidone M,Cossarizza A,Grifoni D,Kofler B,Malanchi I,Porcelli AM,Gasparre G
12-5920-82 was used in Flow Cytometry to demonstrate that respiratory complex I-deficient tumours survive and carry out angiogenesis, despite their inability to stabilise Hypoxia Inducible Factor-1 alpha.
Fri Feb 22 00:00:00 EST 2019
Oral administration of taheebo (Tabebuia avellanedae Lorentz ex Griseb.) water extract prevents DSS-induced colitis in mice by up-regulating type II T helper immune responses.
BMC complementary and alternative medicine
Park HJ,Lee SW,Kwon DJ,Heo SI,Park SH,Kim SY,Hong S
12-5920 was used in Flow cytometry/Cell sorting to show that taheebo water extract (TWE) is an excellent natural product with therapeutic effects to help improve inflammatory disorders such as colitis.
Wed Sep 06 00:00:00 EDT 2017
Phenotypic switch in lung interstitial macrophage polarization in an ovalbumin-induced mouse model of asthma.
Experimental and therapeutic medicine
Nie H,Wang A,He Q,Yang Q,Liu L,Zhang G,Huang Y,Ding X,Yu H,Hu S
12-5920-82 was used in Flow Cytometry to observe the phenotypic characteristics of lung interstitial macrophages in an ovalbumin-induced mouse model of asthma.
Tue Aug 01 00:00:00 EDT 2017
Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival.
Buscher K,Ehinger E,Gupta P,Pramod AB,Wolf D,Tweet G,Pan C,Mills CD,Lusis AJ,Ley K
12-5920 was used in Flow cytometry/Cell sorting to highlight natural activation diversity as a disease relevant dimension in macrophage biology.
Mon Jul 24 00:00:00 EDT 2017
Location of tumor affects local and distant immune cell type and number.
Immunity, inflammation and disease
Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S
12-5920 was used in Flow cytometry/Cell sorting to demonstrate that location of tumour, and not simply the tumour itself, has a definitive role in regulating immune effectors.
Wed Mar 01 00:00:00 EST 2017
Modulation of Microglial Cell Fcγ Receptor Expression Following Viral Brain Infection.
Chauhan P,Hu S,Sheng WS,Prasad S,Lokensgard JR
12-5920 was used in Flow cytometry/Cell sorting to demonstrate that neuro-inflammation following viral infection increases expression of activating FcγRs on M1-polarized microglia.
Mon Feb 06 00:00:00 EST 2017
MIF Promotes Classical Activation and Conversion of Inflammatory Ly6C(high) Monocytes into TipDCs during Murine Toxoplasmosis.
Mediators of inflammation
Ruiz-Rosado Jde D,Olguín JE,Juárez-Avelar I,Saavedra R,Terrazas LI,Robledo-Avila FH,Vazquez-Mendoza A,Fernández J,Satoskar AR,Partida-Sánchez S,Rodriguez-Sosa M
12-5920 was used in Flow cytometry/Cell sorting to analyse the role of migration inhibitory factor in the maturation of CD11b(+) and CD8α (+) dendritic cells.
Fri Dec 30 00:00:00 EST 2016
CD4+ T Cells Are as Protective as CD8+ T Cells against Rickettsia typhi Infection by Activating Macrophage Bactericidal Activity.
PLoS neglected tropical diseases
Moderzynski K,Papp S,Rauch J,Heine L,Kuehl S,Richardt U,Fleischer B,Osterloh A
12-5920 was used in Flow cytometry/Cell sorting to demonstrate that CD4+ T cells are as protective as CD8+ T cells against R. typhi, provided that CD4+ TH1 effector cells are present in time to support bactericidal activity of phagocytes via the release of IFNγ and other factors.
Tue Nov 01 00:00:00 EDT 2016
Liver Necrosis and Lethal Systemic Inflammation in a Murine Model of Rickettsia typhi Infection: Role of Neutrophils, Macrophages and NK Cells.
PLoS neglected tropical diseases
Papp S,Moderzynski K,Rauch J,Heine L,Kuehl S,Richardt U,Mueller H,Fleischer B,Osterloh A
12592082 was used in flow cytometry to investigate the contribution of neutrophils and macrophages during Rickettsia typhi infection
Mon Aug 01 00:00:00 EDT 2016
Persisting Rickettsia typhi Causes Fatal Central Nervous System Inflammation.
Infection and immunity
Osterloh A,Papp S,Moderzynski K,Kuehl S,Richardt U,Fleischer B
12592082 was used in flow cytometry to report the course of Rickettsia typhi infection in RAG1 knockout mice
Sun May 01 00:00:00 EDT 2016
Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages.
Lee SW,Park HJ,Jeon SH,Lee C,Seong RH,Park SH,Hong S
12-5920 was used in Flow cytometry/Cell sorting to investigate the role of a SWI3-related gene in experimental autoimmune encephalomyelitis development.
Mon Apr 11 00:00:00 EDT 2016
Impaired gp100-Specific CD8(+) T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model.
The Journal of investigative dermatology
Mairhofer DG,Ortner D,Tripp CH,Schaffenrath S,Fleming V,Heger L,Komenda K,Reider D,Dudziak D,Chen S,Becker JC,Flacher V,Stoitzner P
12-5920 was used in Flow cytometry/Cell sorting to characterise the immune status and functional properties of immune cells in a spontaneous melanoma mouse model.
Sun Nov 01 00:00:00 EDT 2015
Commensal Gram-positive bacteria initiates colitis by inducing monocyte/macrophage mobilization.
Nakanishi Y,Sato T,Ohteki T
Thu Jan 01 00:00:00 EST 2015