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Product Details
MA5-31754
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
7G8D3
Immunogen
Purified recombinant fragment of human GRM7 (AA: 454-590) expressed in E. coli.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2787377
Product Specific Information
MA5-31754 has been tested in indirect ELISA.
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ40498; glutamate receptor; glutamate receptor, metabotropic 7; Metabotropic glutamate receptor 7; mGluR7; protein phosphatase 1, regulatory subunit 87
Gene Aliases: GLUR7; GPRC1G; GRM7; MGLU7; MGLUR7; PPP1R87
UniProt ID: (Human) Q14831
Entrez Gene ID: (Human) 2917
Molecular Function:
G-protein coupled receptor
conditioned taste aversion
behavioral fear response
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
sensory perception of sound
sensory perception of smell
short-term memory
negative regulation of glutamate secretion
transmission of nerve impulse
adult behavior
negative regulation of cAMP biosynthetic process
regulation of cyclase activity
regulation of synaptic transmission, glutamatergic
calcium ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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