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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||GST fusion protein to the N terminus of p107.|
|Contains||0.08% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
p107 is related both in structure and function to the retinoblastoma tumor suppressor protein and p130 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p107 converts E2F transcription factors from transcriptional activators to transcriptional repressors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases.
MA1-12362 was used in western blot to study the ability of the Discodermia calyx toxin calyculin A to block calcium channels and inhibit serine/threonine phosphatases
|Holy M,Brautigan DL||Toxins (4:940)||2012|
107 kDa retinoblastoma-associated protein; Retinoblastoma related protein; retinoblastoma-like 1; retinoblastoma-like protein 1
AW547426; CP107; p107; PRB1; RBL1