Product References
Hepatic progenitor cells of biliary origin with liver repopulation capacity.
Nature cell biology
Lu WY,Bird TG,Boulter L,Tsuchiya A,Cole AM,Hay T,Guest RV,Wojtacha D,Man TY,Mackinnon A,Ridgway RA,Kendall T,Williams MJ,Jamieson T,Raven A,Hay DC,Iredale JP,Clarke AR,Sansom OJ,Forbes SJ
MA5-15244 was used in immunohistochemistry - paraffin section to study liver repopulation capacity of biliary origin hepatic progenitor cells
Sat Aug 01 00:00:00 EDT 2015
IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes.
Cell proliferation
Hsieh WL,Huang YH,Wang TM,Ming YC,Tsai CN,Pang JH
MA5-15244 was used in western blot to identify the role of IFI27 in the cell proliferation of human epidermal keratinocytes
Wed Apr 01 00:00:00 EDT 2015
TP53 transcription factor for the NEDD9/HEF1/Cas-L gene: potential targets in Non-Small Cell Lung Cancer treatment.
Scientific reports
Rousseau B,Jacquot C,Le Palabe J,Malleter M,Tomasoni C,Boutard T,Sakanyan V,Roussakis C
MA5-15244 was used in ChIP assay to elucidate the therapeutic use of triazine A190
Tue May 26 00:00:00 EDT 2015
Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.
Cell death and differentiation
Phesse TJ,Myant KB,Cole AM,Ridgway RA,Pearson H,Muncan V,van den Brink GR,Vousden KH,Sears R,Vassilev LT,Clarke AR,Sansom OJ
MA5-15244 was used in immunohistochemistry to study apoptosis induced by p53 in response to DNA damage and the essential role of c-Myc
Sun Jun 01 00:00:00 EDT 2014
Zyxin is a novel target for β-amyloid peptide: characterization of its role in Alzheimer's pathogenesis.
Journal of neurochemistry
Lanni C,Necchi D,Pinto A,Buoso E,Buizza L,Memo M,Uberti D,Govoni S,Racchi M
MA5-15244 was used in immunoprecipitation to study the ability of beta-amyloid (1-40) and beta-amyloid (1-42) to interfere with the expression of zyxin
Sat Jun 01 00:00:00 EDT 2013
Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression.
Cell death & disease
Buizza L,Prandelli C,Bonini SA,Delbarba A,Cenini G,Lanni C,Buoso E,Racchi M,Govoni S,Memo M,Uberti D
MA5-15244 was used in immunoprecipitation to study the role of p53 with an altered conformation in reduced GAP-43 expression, impaired neuronal function and reduced apoptosis
Thu Feb 07 00:00:00 EST 2013
Two mechanisms underlying the loss of p16(Ink4a) function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence.
Mechanisms of ageing and development
Wu X,Jia S,Zhang X,Si X,Tang W,Luo Y
MA5-15244 was used in western blot to study the tumorigenic consequences of different mechanisms of p16(Ink4a) loss of function
Wed Aug 01 00:00:00 EDT 2012
UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis.
Carcinogenesis
Rebel HG,Bodmann CA,van de Glind GC,de Gruijl FR
MA5-15244 was used in immunohistochemistry to investigate the origin of UV-induced squamous cell carcinomas.
Thu Mar 01 00:00:00 EST 2012
Searching for predictive blood biomarkers: misfolded p53 in mild cognitive impairment.
Current Alzheimer research
Stanga S,Lanni C,Sinforiani E,Mazzini G,Racchi M
MA5-15244 was used in flow cytometry to study the ability of cytofluorometric measurement of misfolded p53 in venous blood samples to predict progression from mild cognitive disorder to Alzheimer's disease
Sat Dec 01 00:00:00 EST 2012
Molecular profiling of parathyroid hyperplasia, adenoma and carcinoma.
Pathology oncology research : POR
Árvai K,Nagy K,Barti-Juhász H,Peták I,Krenács T,Micsik T,Végső G,Perner F,Szende B
MA5-15244 was used in immunohistochemistry to study the molecular profiles of parathyroid hyperplasia, adenoma and carcinoma
Sun Jul 01 00:00:00 EDT 2012
Topical grape seed proanthocyandin extract reduces sunburn cells and mutant p53 positive epidermal cell formation, and prevents depletion of Langerhans cells in an acute sunburn model.
Photomedicine and laser surgery
Yuan XY,Liu W,Hao JC,Gu WJ,Zhao YS
MA5-15244 was used in immunohistochemistry to study the protective effects of topical grape seed proanthocyandin extract in an acute sunburn model
Sun Jan 01 00:00:00 EST 2012
Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors.
Diagnostic pathology
Hewedi IH,Radwan NA,Shash LS
MA5-15244 was used in immunohistochemistry to study the diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors
Thu Jan 05 00:00:00 EST 2012
The gain of function of p53 mutant p53S in promoting tumorigenesis by cross-talking with H-RasV12.
International journal of biological sciences
Jia S,Zhao L,Tang W,Luo Y
MA5-15244 was used in ChIP assay to study the role of H-RasV12 in the promotion of tumorigenesis by a gain of function p53 mutant
Thu Aug 23 00:00:00 EDT 2012
CIS is a surrogate marker of genetic instability and field carcinogenesis in the urothelial mucosa.
Urologic oncology
Palmeira C,Lameiras C,Amaro T,Lima L,Koch A,Lopes C,Oliveira PA,Santos L
MA5-15244 was used in immunohistochemistry to study the value of CIS as a surrogate marker of genetic instability and field carcinogenesis in the urothelial mucosa
Fri Jul 22 00:00:00 EDT 2011
Exploring antibody recognition of sequence space through random-sequence peptide microarrays.
Molecular & cellular proteomics : MCP
Halperin RF,Stafford P,Johnston SA
MA5-15244 was used in western blot to study the feasibility of using a random peptide microarray to map antibody epitopes
Tue Mar 01 00:00:00 EST 2011
Pu-erh tea inhibits tumor cell growth by down-regulating mutant p53.
International journal of molecular sciences
Zhao L,Jia S,Tang W,Sheng J,Luo Y
MA5-15244 was used in western blot to investigate the effect of Pu-erh tea on cancer cell growth and its mechanism
Tue Dec 30 00:00:00 EST 2014
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma.
Cancer cell
Mir SE,De Witt Hamer PC,Krawczyk PM,Balaj L,Claes A,Niers JM,Van Tilborg AA,Zwinderman AH,Geerts D,Kaspers GJ,Peter Vandertop W,Cloos J,Tannous BA,Wesseling P,Aten JA,Noske DP,Van Noorden CJ,Würdinger T
MA5-15244 was used in western blot to perform bioinformatic analyses of kinase expression to determine the role of WEE1 in glioblastoma
Tue Sep 14 00:00:00 EDT 2010
Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Graziano SL,Gu L,Wang X,Tatum AH,Vollmer RT,Strauss GM,Kratzke R,Dudek AZ,Vokes EE,Green MR
MA5-15244 was used in immunohistochemistry to evaluate mucin and p53 expression as prognostic markers for stage IB non-small cell lung cancer
Tue Jun 01 00:00:00 EDT 2010
Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Lanni C,Racchi M,Stanga S,Mazzini G,Ranzenigo A,Polotti R,Memo M,Govoni S,Uberti D
MA5-15244 was used in flow cytometry to study the predictive value of unfolded p53 in blood for the development of Alzheimer's disease
Thu Jul 08 00:00:00 EDT 2010
Wild type but not mutant APP is involved in protective adaptive responses against oxidants.
Amino acids
Cenini G,Maccarinelli G,Lanni C,Bonini SA,Ferrari-Toninelli G,Govoni S,Racchi M,Butterfield DA,Memo M,Uberti D
MA5-15244 was used in immunoprecipitation to investigate the role of APP in protective adaptive responses agaist oxidants
Tue Jun 01 00:00:00 EDT 2010
ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition.
Gastroenterology
Herbst A,Bommer GT,Kriegl L,Jung A,Behrens A,Csanadi E,Gerhard M,Bolz C,Riesenberg R,Zimmermann W,Dietmaier W,Wolf I,Brabletz T,Göke B,Kolligs FT
MA5-15244 was used in immunohistochemistry to study the expression and role of ITF-2B in colorectal carcinogenesis
Sat Aug 01 00:00:00 EDT 2009
Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells.
Toxicology
Wang Z,Qi Y,Chen Q,Yang D,Tang S,Jin X,Gao J,Fu J,Zhou Z,Wang J,Xiao X
MA5-15244 was used in western blot to study the role of cyclin A in the protective effect of p53 from benzopyrene carcinogenic toxicity in A549 cells
Wed Feb 04 00:00:00 EST 2009
Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.
Cancer research
Holcomb VB,Rodier F,Choi Y,Busuttil RA,Vogel H,Vijg J,Campisi J,Hasty P
MA5-15244 was used in western blot to investigate the effect of Ku80 on tumor growth
Sat Nov 15 00:00:00 EST 2008
The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine.
Phytotherapy research : PTR
Agrawal A,Sharma M,Rai SK,Singh B,Tiwari M,Chandra R
MA5-15244 was used in immunohistochemistry to report that pretreatment of Wistar rats with the aqueous extract of Asparagus racemosus prevents diethylnitrosamine-induced damage
Mon Sep 01 00:00:00 EDT 2008
Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy.
International journal of colorectal disease
Terzi C,Canda AE,Sagol O,Atila K,Sonmez D,Fuzun M,Gorken IB,Oztop I,Obuz F
MA5-15244 was used in immunohistochemistry to study the value of survivin, p53, and Ki-67 in predicting the response to preoperative chemoradiotherapy in locally advanced rectal cancer
Tue Jan 01 00:00:00 EST 2008
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.
BMC cancer
Reed KR,Meniel VS,Marsh V,Cole A,Sansom OJ,Clarke AR
MA5-15244 was used in immunohistochemistry to study the role of p53 in modulating the immediate phenotype of Apc loss in the intestine
Thu Jun 05 00:00:00 EDT 2008
Quantitative assessment of the p53-Mdm2 feedback loop using protein lysate microarrays.
Cancer research
Ramalingam S,Honkanen P,Young L,Shimura T,Austin J,Steeg PS,Nishizuka S
MA5-15244 was used in immunohistochemistry to experimentally assess a mathematical model of the p53-Mdm2 feedback loop
Sun Jul 01 00:00:00 EDT 2007
Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals.
Cell death and differentiation
Preyer M,Shu CW,Wang JY
MA5-15244 was used in western blot to investigate Abl nuclear import in DNA damage-induced apoptosis
Fri Jun 01 00:00:00 EDT 2007
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.
Cell death and differentiation
Bifsha P,Landry K,Ashmarina L,Durand S,Seyrantepe V,Trudel S,Quiniou C,Chemtob S,Xu Y,Gravel RA,Sladek R,Pshezhetsky AV
MA5-15244 was used in western blot to study the involvement of the ubiquitin pathway in lysosomal storage disorders
Thu Mar 01 00:00:00 EST 2007
53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy.
Oncogene
Clarke AR,Jones N,Pryde F,Adachi Y,Sansom OJ
MA5-15244 was used in immunohistochemistry to study the role of 53BP1 in mediating apoptosis and proliferation in mouse small intestine following gamma-irradiation
Thu Sep 20 00:00:00 EDT 2007
The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter.
Oncogene
Zhu Q,Wani G,Yao J,Patnaik S,Wang QE,El-Mahdy MA,Praetorius-Ibba M,Wani AA
MA5-15244 was used in immunoprecipitation and western blot to study the role of the ubiquitin-proteasome system in the transcriptional activation function of p53
Thu Jun 21 00:00:00 EDT 2007
Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell.
Chinese medical journal
Wu ZQ,Zhang R,Chao C,Zhang JF,Zhang YQ
MA5-15244 was used in western blot to study the mechanism by which a histone deacetylase inhibitor induces apoptosis in human gastric cancer cells
Wed Dec 05 00:00:00 EST 2007
Growth stimulation of UV-induced DNA damage retaining epidermal basal cells gives rise to clusters of p53 overexpressing cells.
DNA repair
Nijhof JG,Mulder AM,Speksnijder EN,Hoogervorst EM,Mullenders LH,de Gruijl FR
MA5-15244 was used in immunohistochemistry to investigate the mechanism for the pathogenesis of UV-induced melanomas
Thu Nov 01 00:00:00 EDT 2007
P53 expression between 13-27 weeks old human male fetus gonads.
Journal of molecular histology
Tosun M,Tosun E,Kalkan S,Avunduk MC
MA5-15244 was used in immunohistochemistry to study the time-course of p53 expression in human male fetal gonads
Wed Aug 01 00:00:00 EDT 2007
Diabetes alters expression of p53 and c-myc in different stages of oral oncogenesis.
Anticancer research
Vairaktaris E,Kalokerinos G,Goutzanis L,Spyridonidou S,Vassiliou S,Derka S,Nkenke E,Yapijakis C,Vylliotis A,Lazaris A,Patsouris E
MA5-15244 was used in immunohistochemistry to study the expression of p53 and c-myc by normal and diabetic rats in a model of oral carcinogenesis
Fri Jul 27 00:00:00 EDT 2007
Multiple initial culture conditions enhance the establishment of cell lines from primary ovarian cancer specimens.
In vitro cellular & developmental biology. Animal
Bertozzi CC,Chang CY,Jairaj S,Shan X,Huang J,Weber BL,Chu CS,Carroll RG
MA5-15244 was used in immunocytochemistry to establish stable ovarian tumor cell lines
Wed Dec 27 00:00:00 EST 2006
Mutations in Apc and p53 synergize to promote mammary neoplasia.
Cancer research
Méniel V,Hay T,Douglas-Jones A,Sansom OJ,Clarke AR
MA5-15244 was used in immunohistochemistry to study the synergistic role of Apc and p53 mutations in promoting mammary neoplasia
Sat Jan 15 00:00:00 EST 2005
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
Genes & development
Laud PR,Multani AS,Bailey SM,Wu L,Ma J,Kingsley C,Lebel M,Pathak S,DePinho RA,Chang S
MA5-15244 was used in western blot to study the role elevated telomere-telomere recombination and escape from senescence in the pathogenesis of Werner Syndrome
Tue Nov 01 00:00:00 EST 2005
Cell death induced by taxanes in breast cancer cells: cytochrome C is released in resistant but not in sensitive cells.
Anticancer research
Ehrlichová M,Koc M,Truksa J,Naldová Z,Václavíková R,Kovárr J
MA5-15244 was used in immunocytochemistry to study the mechanisms responsible for the resistance of breast cancer cells to taxanes
Thu Jan 05 00:00:00 EST 2006
A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers.
Molecular & cellular proteomics : MCP
Rosas-Acosta G,Russell WK,Deyrieux A,Russell DH,Wilson VG
MA5-15244 was used in western blot to develop a new method for proteomic studies of SUMO-modified proteins
Sat Jan 01 00:00:00 EST 2005
Effects of extracellular matrix on the morphology and behaviour of rabbit auricular chondrocytes in culture.
Journal of biomedicine & biotechnology
Villar-Suárez V,Colaço B,Calles-Venal I,Bravo IG,Fernández-Alvarez JG,Fernández-Caso M,Villar-Lacilla JM
MA5-15244 was used in immunohistochemistry to investigate cell apoptosis of cultured rabbit auricular chondrocytes under different circumstances
Wed Jun 09 00:00:00 EDT 2010
p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.
Cancer research
Hoogervorst EM,van Oostrom CT,Beems RB,van Benthem J,Gielis S,Vermeulen JP,Wester PW,Vos JG,de Vries A,van Steeg H
MA5-15244 was used in immunohistochemistry to study the role of p53 heterozygosity in increased 2-acetylaminofuorene-induced cancer in DNA repair-deficient Xpa mice
Sun Aug 01 00:00:00 EDT 2004
p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma.
International journal of cancer
Jayasurya R,Francis G,Kannan S,Lekshminarayanan K,Nalinakumari KR,Abraham T,Abraham EK,Nair MK
MA5-15244 was used in immunohistochemistry to study the molecular determinants of the response to radiotherapy in oral carcinoma
Sat May 01 00:00:00 EDT 2004
The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5beta, 6beta-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Mathur S,Kaur P,Sharma M,Katyal A,Singh B,Tiwari M,Chandra R
MA5-15244 was used in immunohistochemistry - paraffin section to show that 1-oxo-5beta, 6beta-epoxy-witha-2-enolide prevents the incidence of skin carcinoma induced by UV B radiation in rats
Thu Jul 01 00:00:00 EDT 2004
Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation.
Journal of virology
Ali SH,Kasper JS,Arai T,DeCaprio JA
MA5-15244 was used in western blot to study the role of p185/Cul7 binding to simian virus 40 large T antigen in cellular transformation
Mon Mar 01 00:00:00 EST 2004
p53 targets simian virus 40 large T antigen for acetylation by CBP.
Journal of virology
Poulin DL,Kung AL,DeCaprio JA
MA5-15244 was used in western blot to study the role of p53 in targeting simian virus 40 large T antigen for acetylation by CBP
Sun Aug 01 00:00:00 EDT 2004
Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA-mediated activation of phosphatidylinositol 3-kinase.
Molecular endocrinology (Baltimore, Md.)
Facchetti M,Uberti D,Memo M,Missale C
MA5-15244 was used in immunoprecipitation to study the role of trkA and PI3kinase in the restorationof p53 function by NGF in pituitary tumor cell lines
Thu Jan 01 00:00:00 EST 2004
Immunohistochemical studies concerning the neuronal cell cycle of the cat using PCNA, Ki-67 and p53 markers.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
Gruber A,Schmidt P,Url A
MA5-15244 was used in immunohistochemistry to study the immunohistochemistry of markers of the cat neuronal cell cycle
Wed Dec 01 00:00:00 EST 2004
Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression.
Oncogene
Gingras B,Rodier G,Giasson E,Coulombe P,Chassagne C,Meloche S
MA5-15244 was used in western blot to study the role of angiotensin II receptor expression in Cdk4 downregulation and inhibition of cell proliferation
Thu May 01 00:00:00 EDT 2003
Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers.
Cancer science
Masuda N,Kato H,Nakajima T,Sano T,Kashiwabara K,Oyama T,Kuwano H
MA5-15244 was used in immunohistochemistry to investigate the correlation between changes of p73 and p21 level and esophageal cancer status
Tue Jul 01 00:00:00 EDT 2003
Changes in expression and immunolocalization of protein associated with toxic bile salts-induced apoptosis in rat hepatocytes.
Archives of toxicology
Oh SH,Yun KJ,Nan JX,Sohn DH,Lee BH
MA5-15244 was used in western blot to study the molecular mechanism of toxic bile salts-induced apoptosis in rat hepatocytes
Sat Feb 01 00:00:00 EST 2003
Oral cytology assessment by flow cytometry of DNA adducts, aneuploidy, proliferation and apoptosis shows differences between smokers and non-smokers.
Oral oncology
Schwartz JL,Muscat JE,Baker V,Larios E,Stephenson GD,Guo W,Xie T,Gu X,Chung FL
MA5-15244 was used in immunohistochemistry to study the differences in oral cytology between smokers and non-smokers
Mon Dec 01 00:00:00 EST 2003
The predictive value of neuroendocrine markers and p53 for response to chemotherapy and survival in patients with advanced non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands)
Gajra A,Tatum AH,Newman N,Gamble GP,Lichtenstein S,Rooney MT,Graziano SL
MA5-15244 was used in immunohistochemistry to study the value of neuroendocrine markers and p53 for predicting chemotherapeutic response and survival in advanced non-small cell lung cancer
Wed May 01 00:00:00 EDT 2002
Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients.
Journal of cell science
Uberti D,Carsana T,Bernardi E,Rodella L,Grigolato P,Lanni C,Racchi M,Govoni S,Memo M
MA5-15244 was used in western blot to study the selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients
Thu Aug 01 00:00:00 EDT 2002
Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2.
Molecular and cellular biology
Smith KS,Rhee JW,Cleary ML
MA5-15244 was used in immunoprecipitation to study the role of BCL-2 in the transformation of bone marrow B-cell progenitors by E2a-Hlf
Fri Nov 01 00:00:00 EST 2002
The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63.
The Journal of biological chemistry
Calabrò V,Mansueto G,Parisi T,Vivo M,Calogero RA,La Mantia G
MA5-15244 was used in western blot to investigate the effect of MDM2 oncoprotein on the expression of p63
Fri Jan 25 00:00:00 EST 2002
Use of neuroendocrine markers, p53, and HER2 to predict response to chemotherapy in patients with stage III non-small cell lung cancer: a Cancer and Leukemia Group B study.
Lung cancer (Amsterdam, Netherlands)
Graziano SL,Tatum A,Herndon JE,Box J,Memoli V,Green MR,Kern JA
MA5-15244 was used in immunohistochemistry to study whether neuroendocrine markers, p53, and HER2 can predict response to chemotherapy in patients with stage III non-small cell lung cancer
Thu Oct 04 00:00:00 EDT 2001