|Tested species reactivity||Human, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues A K E G V V A A A E K T K Q G V of a consensus part of human alpha-, beta-, and gamma synuclein proteins.|
|Storage buffer||whole serum|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-18253 detects alpha, beta, and gamma Synuclein from human and rat samples.
PA1-18253 has been successfully used in immunohistochemistry and Western blot procedures.
The PA1-18253 immunogen is a synthetic peptide corresponding to residues A K E G V V A A A E K T K Q G V of a consensus part of human alpha-, beta-, and gamma synuclein proteins, conjugated to diphteria toxoid.
Reconstitute with 100 ul of distilled water.
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.