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Fueling acceleration

From equipment and raw materials to results

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Accelerate your bioprocess development journey

Accelerating biomanufacturing requires integrated solutions—not standalone components. Integrating a high-performing cell line and media, high-density cell banking, N-1 perfusion, intensified fed-batch culturing, and single-use systems in the upstream workflow with advanced purification techniques, such as high-capacity chromatography resins, inline dilution, and sustainable buffer strategies in the downstream workflow can enhance productivity to improve asset utilisation, reduce lifecycle COGs, and support reliable, scalable commercial supply.

Upstream process intensification

Increasing upstream mAb productivity is challenging—higher titers require careful control of cell health, density, media, and scalability without compromising quality. Integrating the CHOvantage cell line, a high performance medium, high-density cell banking, N-1 perfusion, intensified fed-batch culturing, and single-use bioreactor and centrifugation systems can enhance mAb productivity through enhanced efficiency, cost-effectiveness, and sustainability.

 

Achieve up to:

163% increase in cell titer*

2.6-fold increase in kg/year output*

50% reduction in upstream processing batch time*

50% reduction in cost per gram with intensified upstream processes*

*Sources: White paper: Optimizing monoclonal antibody production

Poster: Intensifying technologies to increase monoclonal antibody upstream process productivity

Disclaimer: The data and case studies presented are provided for informational purposes only and illustrate potential process and economic outcomes associated with Thermo Fisher Scientific bioprocess technologies. Results are based on modeled scenarios and representative examples and are not intended to predict or guarantee actual process performance or financial outcomes. Actual results may vary depending on process parameters, equipment configuration, scale, and facility design.

 

 

Scale-up manufacturing with Single-Use technologies

The Thermo Scientific DynaDrive Single-Use Bioreactor (S.U.B.) platform  supports efficient scalability from 5 L to 5,000 L, enabling consistent performance from process development to commercial manufacturing.
 

Its advanced impeller and vessel design provide high mass transfer, excellent turndown, and reliable performance across diverse cell lines and modalities—helping you scale faster, simplify operations, and produce with confidence.

 

 

Features of Dynadrive S.U.B. platform:

5L to 5,000 L scalability

Decrease up to 20%* of workflow duration

High performance, flexible design

*Increase of 141 experiments per year compared to 111 with glass bioreactors. Source: Single-use technology infographic

 

 

Accelerating biologics manufacturing through efficient tech transfer: Case study

Enabling scalable mAb development with the DynaDrive Bioreactor

A global biopharma company sought a scalable mAb manufacturing platform to support multiple products and accelerate tech transfer to internal and CMO sites. To meet growing demand while controlling costs and risk, they needed a solution that could help them transition from development to GMP production.
 

By integrating high-quality raw materials with the DynaDrive Single-Use Bioreactor (S.U.B.) platform, Thermo Fisher Scientific enabled reliable scale-up and efficient tech transfer to a pre-validated CDMO—enabling continuity, speed, and readiness for expansion.

 

By combining scalable technology with a streamlined tech transfer strategy, the approach helped to reduce CAPEX and OPEX, shortened setup times, and helped reduce process flexibility*.

*This case study example is for illustrative purposes only; results may vary.

 

 

Accelerate downstream processing

Increase productivity and accelerate your downstream process with integrated purification technologies designed to improve efficiency, reduce cost of goods, and maintain consistent product quality. Implementing advanced purification techniques, such as high-capacity chromatography, resins, inline dilution, and sustainable buffer strategies can support productivity through enhanced efficiency, cost-effectiveness, and sustainability.

 

Achieve up to:

37% reduced resin cost per batch*

Reduced downstream and process liquid prep footprint by 30%*

$2M in reduced costs per year due to outsourced process liquid production*

*Source: https://documents.thermofisher.com/TFS-Assets/BPD/posters/mab-advanced-downstream-purification-strategies-poster.pdf

Technical services

Strengthen your workflow with technical services


Alongside our high-performing products and solutions, we offer customizable services tailored to your unique challenges. From custom chromatography solutions to Gibco by Design, we offer flexible support that can be tailored to each process. Technical specialists and regulatory insight help lower risk and strengthen long-term productivity.

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.