Applied Biosystems™

Axiom™ Biobank Plus Genotyping Array

Catalog number:  000854

 Related applications: Microarray Analysis

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Description

The Axiom™ Biobank Plus Genotyping Arrays were designed by and for thought leaders in the human genetics community for high-throughput, high-value genotyping of large sample cohorts to explore the genetics of complex diseases and translational research with a single comprehensive low-cost solution.

GWAS
• Intelligent marker selection enables imputation of millions of additional SNPs
• The genomic content module of each array is optimized for specific populations and is customizable to any 1000 Genomes population study by adding additional markers of your choosing

Transplant
• Content specific for transplantation research including functional variants, loss-of-function markers, and copy number
• Immune function, including content covering the major histocompatibility complex (MHC), human leukocyte antigen (HLA), and killer-cell immunoglobulin-like receptors (KIR)

Pharmacogenomic markers
• Markers were selected to represent phases of absorption, distribution, metabolism, and excretion (ADME)

Inflammation and HLA
• Contains markers with evidence for association with autoimmune and inflammation
• Covers variants in genes in the HLA and KIR regions known to be important in immune response

Exome
• Rare, non-synonymous coding SNPs and indels in protein coding regions of the genome
• A majority of variants are rare with minor allele frequency (MAF) <1%
• Newly discovered loss-of-function content
• SNPs and indels identified from a sequencing initiative of 26,000 individuals
• Known disease-causing mutations eQTLs

• Markers that have known associations to RNA expression traits

• Captures unique eQTLs contained in the NCBI Genotype-Tissue Expression (GTEx) eQTL database, GEUVIDAS project, and several other discovery projects


Human disease
• Alzheimer-s disease, including coverage of ApoE
• Blood phenotypes
• Cancer common variants
• Cardiometabolic


Choose your content
• Order the pre-designed array and customize it with markers of your choice
• Custom markers may be de novo or selected from the Applied Biosystems Axiom Genomic Database of genotype-tested markers

Please note: Reagent kits do not include plastic consumables required to run the assay on the Beckman Biomek™ FXP Target Prep Express System. Please contact us for a list of required plastic consumables.

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Array Format: 96-array plate
Array Type: Genotyping
Number of Arrays: 1 array
Product Size: 1 each
Species: Human

Documents

Manuals & protocols