Tantalum(V) chloride is used to form mixed chloro-aryloxide compounds, such as [Ta(OC6H3-2,6-i-Pr2)2Cl3]2, which form pyridine or phosphine adducts with a distorted six-coordinate geometry. It is also used as a starting material for new edge-bridged octahedral M6 cluster compounds such as CsErTa6Cl18.

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