Sodium telluride is used as a semiconductor, as a reducing agent and to prepare organic tellurium compounds. It is used in the reduction of aromatic carbonyl compounds to alcohols. It is also used in the preparation of pyrrolo[2,3-d]pyrimidines (7-deaza-9H-purines) from aromatic nitriles. It is used to prepare nanocrystalline zinc telluride.

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