Thermo Scientific™

Q Exactive™ HF-X Hybrid Quadrupole-Orbitrap™ Mass Spectrometer

 Related applications:
Industrial Mass Spectrometry

The Thermo Scientific™ Q Exactive™ HF-X Hybrid Quadrupole-Orbitrap™ Mass Spectrometer rises to the occasion and sets new standards in sensitivity, performance and productivity. The Q Exactive HF-X Mass Spectrometer uses a high-capacity transfer tube for maximum ion loading, an electrodynamic ion funnel that accomodates and transmits ions over a broader mass range, and a high-field Thermo Scientific™ Orbitrap™ mass analyzer. Together, these components enable fast identification and analysis of peptides, label-free and TMT quantitation, top-down proteomics analyses, sophisticated DDA and DIA, dynamic Retention Time PRM and BioPharma characterization.

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Smart, Consistent and Productive
  • Novel architecture, including a high capacity transfer tube (HCTT) and electrodynamic ion funnel, increase ion transmission and boost sensitivity for all analytes ranging from small molecules to native antibodies.
  • Superior consistency and performance set new standards for quantitative accuracy, sensitivity and reproducibility, facilitating even the most rigorous research workflows during large-scale studies of challenging protein samples.
  • Functional versatility enables the use of this single, high-performance platform in both bottom-up and top-down proteomics studies.
  • Increased acquisition speed and a sophisticated DDA+ workflow dramatically improve peptide sequencing speed and depth.
  • Robust workflows advance biomarker verification and analysis via parallel reaction monitoring (PRM), with high-resolution data-independent acquisition (DIA) and automated retention time correction.
  • Available with the powerful Thermo Scientific™ Q Exactive™ BioPharma option to support all workflows in biotherapeutics characterization with enhanced sensitivity, from peptide mapping to analysis of intact proteins under native conditions.

Take discovery and sample analysis to the next level with our innovative cloud solutions

MS Instrument Connect allows you to:

  • Schedule your equipment and monitor experiments
  • Monitor real-time instrument status
  • Track system utilization and historical events
  • Stay informed when runs complete or system errors occur through email

Three ways to spend less and get more

Three ways to spend less and get more

Upgrade your ability to achieve new scientific discoveries faster with Thermo Scientific Orbitrap mass analyzers that set new standards in sensitivity, performance and productivity. Or take advantage of upgrades to extend your current Thermo Scientific LC-MS system capabilities.

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Manuals & protocols