Q Exactive™ HF-X Hybrid Quadrupole-Orbitrap™ Mass Spectrometer

Thermo Scientific™  Related applications: Industrial Mass Spectrometry

The Thermo Scientific™ Q Exactive™ HF-X Hybrid Quadrupole-Orbitrap™ Mass Spectrometer rises to the occasion and sets new standards in sensitivity, performance and productivity. The Q Exactive HF-X Mass Spectrometer uses a high-capacity transfer tube for maximum ion loading, an electrodynamic ion funnel that accomodates and transmits ions over a broader mass range, and a high-field Thermo Scientific™ Orbitrap™ mass analyzer. Together, these components enable fast identification and analysis of peptides, label-free and TMT quantitation, top-down proteomics analyses, sophisticated DDA and DIA, dynamic Retention Time PRM and BioPharma characterization.

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Description

Smart, Consistent and Productive
  • Novel architecture, including a high capacity transfer tube (HCTT) and electrodynamic ion funnel, increase ion transmission and boost sensitivity for all analytes ranging from small molecules to native antibodies.
  • Superior consistency and performance set new standards for quantitative accuracy, sensitivity and reproducibility, facilitating even the most rigorous research workflows during large-scale studies of challenging protein samples.
  • Functional versatility enables the use of this single, high-performance platform in both bottom-up and top-down proteomics studies.
  • Increased acquisition speed and a sophisticated DDA+ workflow dramatically improve peptide sequencing speed and depth.
  • Robust workflows advance biomarker verification and analysis via parallel reaction monitoring (PRM), with high-resolution data-independent acquisition (DIA) and automated retention time correction.
  • Available with the powerful Thermo Scientific™ Q Exactive™ BioPharma option to support all workflows in biotherapeutics characterization with enhanced sensitivity, from peptide mapping to analysis of intact proteins under native conditions.


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