A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transduction.
AuthorsNewton-Nash DK, Newman PJ
JournalJ Immunol
PubMed ID10395658
'Platelet-endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets. The PECAM-1 extracellular domain has six Ig-homology domains that share sequence similarity with cellular adhesion molecules. The PECAM-1 cytoplasmic domain contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) that, ... More
PECAM-1 ligation negatively regulates TLR4 signaling in macrophages.
AuthorsRui Y, Liu X, Li N, Jiang Y, Chen G, Cao X, Wang J
JournalJ Immunol
PubMed ID18025177
'Uncontrolled TLR4 signaling may induce excessive production of proinflammatory cytokines and lead to harmful inflammation; therefore, negative regulation of TLR4 signaling attracts much attention now. PECAM-1, a member of Ig-ITIM family, can mediate inhibitory signals in T cells and B cells. However, the role and the mechanisms of PECAM-1 in ... More
PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.
AuthorsNewman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA
JournalScience
PubMed ID1690453
'An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained ... More
PECAM-1: a multi-functional molecule in inflammation and vascular biology.
AuthorsWoodfin A, Voisin MB, Nourshargh S
JournalArterioscler Thromb Vasc Biol
PubMed ID17872453
Platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) is a molecule expressed on all cells within the vascular compartment, being expressed to different degrees on most leukocyte sub-types, platelets, and on endothelial cells where its expression is largely concentrated at junctions between adjacent cells. As well as exhibiting adhesive properties, ... More
Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression.
AuthorsSun J, Williams J, Yan HC, Amin KM, Albelda SM, DeLisser HM
JournalJ Biol Chem
PubMed ID8702505
PECAM-1/CD31 is vascular cell adhesion and signaling molecule of the Ig superfamily that plays a role in neutrophil recruitment at inflammatory sites and may be involved the release of leukocytes from the bone marrow and in cardiovascular development. The interactions of PECAM-1 with its ligands are complex in that it ... More