See the new Lipofectamine® RNAiMAX Transfection Reagent protocol—now optimized for efficiency, viability and reproducibility

Lipofectamine® RNAiMAX Transfection Reagent This product, and/or its packaging, incorporates one or more environmental/green features. Click on this icon to learn more.

Catalog number: 13778500

Invitrogen™  Related applications: RNAi | Transfection

Error loading your content!

  Catalog number
Select a plan
Unit size
Price ({{currency}}) Your price ({{currency}}) Availability Qty
{{product.sku}} {{product.sku}}
also known as {{product.formattedSku}} 
{{subscriptionDetails.selectedRatePlan.billingPeriod}} {{subscriptionDetails.selectedRatePlan.billingPeriod}} {{product.availability.message}}
Pro add-ons

Your on-site stock

›› {{supplyCenter.scName}}({{scProduct.stockOnHand}} In stock)
›› {{supplyCenter.scName}}(Out of stock)
›› {{supplyCenter.scName}}
This item is not currently available on-site. Depending on your Supply Center settings you may be able to add the item to cart above else use the Order Non-Stocked Items' tab on the Supply Center home page.
Back to top


Lipofectamine® RNAiMAX Transfection Reagent provides the highest transfection efficiencies on the widest variety of cell types for siRNA-mediated gene knockdown experiments. Lipofectamine® RNAiMAX is a proprietary RNAi-specific cationic lipid formulation designed specifically for the delivery of siRNA and miRNA into all cell types.

With Lipofectamine® RNAiMAX Transfection Reagent you will get:

• Superior transfection efficiency requiring lower RNAi concentrations, leading to more effective gene knockdown with minimal nonspecific effects
• Easy optimization due to minimal cytotoxicity across a 10-fold concentration range of transfection reagent
• Superior transfection efficiencies for miRNA antagonists and mimics
• Compatibility with a broad range of cell types, providing the most versatile approach to all of your gene silencing experiments
• A simple and rapid protocol for consistent and reproducible results

High knockdown in a wide range of cells
Lipofectamine® RNAiMAX Transfection Reagent transfects a wide range of cell types (see figure). For gene silencing, Lipofectamine® RNAiMAX Transfection Reagent's high-efficiency transfections lead to the high levels of gene knockdown needed to achieve convincing results.

Simple, high-throughput–ready transfections
Simply mix Lipofectamine® RNAiMAX Transfection Reagent with siRNA, add to your cells, incubate, and measure gene knockdown. The simplicity and speed combined with high transfection efficiency make Lipofectamine® RNAiMAX Transfection Reagent ideal for high-throughput siRNA transfections. Transfection conditions can be easily established for automated or robotic systems used in such applications.

Find an optimized Lipofectamine® RNAiMAX transfection protocol for your cell line.
For Research Use Only. Not for use in diagnostic procedures.


Cell Type: Established Cell Lines, Hard-to-Transfect Cells, Primary Cells, Stem Cells
Sample Type (Specific): Synthetic siRNA
Transfection Technique: Lipid-Based Transfection
Serum Compatible: Yes
Format: Vial(s)
Product Size: 15 ml
Shipping Condition: Approved for shipment at Room Temperature or on Wet Ice
High Throughput Compatibility: High Throughput-Compatible
Green Features: Sustainable packaging

Contents & storage

Each unit contains one vial of Lipofectamine® RNAiMAX™ Reagent (15 ml). Store at 2–8°C.


Manuals & protocols

Recommended products