Synucleins (α, β, and γ) are a family of cytoplasmic proteins found predominantly, and abundantly, in the brain with cellular distribution concentrated in presynaptic nerve terminals, primarily near vesicles. Synucleins are thought to be involved in neuronal plasticity, synaptic function, and neurodegenerative disease. α-Synuclein (∼18 kDa) is abundant in Lewy Bodies in sporadic Parkinson's Disease (PD) and Dementia with Lewy Bodies (DLB). It has been reported that the NAC fragment from α-synuclein is a major component of amyloid plaques in Alzheimer's Disease. LB509 reacts with α-synuclein but not SM-synuclein. Reactivity has not been observed with γ-synuclein. Positive tissue: Parkinson's disease tissue.
Immunogen: Lewy Bodies purified from patients suffering dementia with Lewy Bodies
Applications: Immunohistochemistry (FFPE)
Pretreatment: Epitope Retrieval: Not required, Enzyme Digestion: Not required