MiTF (Microphthalmia Transcription Factor) Mouse Monclonal Antibody (clone C5+D5), Concentrate

Catalog number: 180369

 Related applications: Anatomical Pathology

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Full Product Description
This antibody reacts specifically with MITF protein. Microphthalmia transcription factor (MITF), a nuclear protein that is essential to the development and survival of melanocytes, regulates the transcription of genes involved in melanogenesis. MITF also serves as a regulator in modulating extracellular signals, such as those triggered by α-MSH and c-Kit ligand. MITF expression is highly conserved in primary and metastatic melanomas, and can be used as a highly sensitive and specific melanocytic marker. Our MITF antibody is a cocktail that includes clones C5 and D5. C5 recognizes both mouse and human MITF, while D5 only recognizes human MITF. A cocktail with both clones has shown greater sensitivity than either alone. Positive tissue: Melanoma.

Clone⁄PAD: C5+D5

Immunogen: N-terminal fragment of human MITF protein

Specificity: MITF (microphthalmia transcription factor)

Reactivity: Human

Applications: Immunohistochemistry (FFPE)

Pretreatment: Epitope Retrieval: Required (Citrate, pH 6.0), Enzyme Digestion: Not required

Expected Staining Pattern: Nuclear
For In Vitro Diagnostic Use.


Reactivity: Human
Validated Application: Immunohistochemistry (FFPE)
Host Species: Mouse
SubClass (Isotype): IgG1
Clonality: Monoclonal
Target Gene: MiTF (Microphthalmia Transcription Factor)
Gene ID: 4286
Label or Dye: Unconjugated
Dilution: Concentrate Antibody
Product Size: 1 mL
Shipping Condition: Wet Ice

Contents & storage

Store in refrigerator (2–8°C).


Manuals & protocols