TS (Thymidylate Synthase) Mouse Monoclonal Antibody (clone 4H4B1), Concentrate

Catalog number: 180399

 Related applications: Anatomical Pathology

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Description

Thymidylate Synthase (TS) catalyzes the reductive methylation of dUMP by 5,10-methylene tetrahydrofolate to generate thymidylate and dihydrofolate. TS is a critical target enzyme in cancer chemotherapy. It has been reported that IHC expression of TS could assist in predicting response of colorectal cancer patients to modulated MTX-5-FU therapy. Positive tissue: Colon cancer/Breast cancer.

Clone/PAD: 4H4B1

Immunogen: Recombinant fusion protein of human thymidylate synthase.

Specificity: Thymidylate Synthase (TS)

Reactivity: Human

Applications: Immunohistochemistry (FFPE)

Pretreatment: Epitope Retrieval: Required (EDTA, pH 8.0), Enzyme Digestion: Not Required

Expected Staining Pattern: Nuclear and cytoplasmic

“This reagent is classified as a medical device in several countries. If it is not regulated as a medical device in specific region, it should be used for laboratory use only.”
For In Vitro Diagnostic Use.

Specifications

Reactivity: Human
Validated Application: Immunohistochemistry (FFPE)
Host Species: Mouse
SubClass (Isotype): IgG1, kappa
Clonality: Monoclonal
Target Gene: Thymidylate Synthase
Gene ID: 7298
Label or Dye: Unconjugated
Dilution: Concentrate Antibody
Product Size: 1 mL
Shipping Condition: Wet Ice

Contents & storage

Store in refrigerator (2–8°C).

Documents

Manuals & protocols