MSH6 Mouse Monoclonal Antibody (clone 2D4B5), Concentrate

Catalog number: 180443

 Related applications: Anatomical Pathology

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Description

Full Product Description
This monoclonal antibody is specific for MSH6. Inherited (germline) mutations in DNA mismatch repair genes such as MLH1, MSH2, MSH3, and MSH6 are the major cause of hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. A characteristic of HNPCC tumors is microsatellite instability (MSI). Detection of microsatellite instability in a tumor sample will increase the probability of detecting a germline mutation in a DNA mismatch repair gene from the patient sample. Thus, MSI analysis is usually performed prior to proceeding with full mutation analysis of mismatch repair genes. Immunohistochemical (IHC) analysis of suspected HNPCC tumor samples has come into favor as a means of screening patients who may carry a mutation or a deletion in one of the mismatch repair (MMR) genes. Positive tissue: Colon carcinoma

Clone_PAD
2D4B5

Immunogen
Recombinant protein corresponding to the N-terminus of human MSH6

Specificity
MSH6

Reactivity
Human

Applications
Immunohistochemistry (FFPE)

Pretreatment
Epitope Retrieval: Required (EDTA, pH 8.0) Enzyme Digestion: Not Required

Staining Pattern
Nuclear

Storage
2-8°C

For In Vitro Diagnostic Use

CE
For In Vitro Diagnostic Use.

Specifications

Reactivity: Human
Validated Application: Immunohistochemistry (FFPE)
Host Species: Mouse
SubClass (Isotype): IgG3, kappa
Clonality: Monoclonal
Target Gene: MSH6
Gene ID: 2956
Label or Dye: Unconjugated
Dilution: Concentrate Antibody
Product Size: 1 mL
Shipping Condition: Wet Ice

Contents & storage

Store in refrigerator (2–8°C).

Documents

Manuals & protocols