MSH2 Mouse Monclonal Antibody (clone FE11), Concentrate

Catalog number: 182343

 Related applications: Anatomical Pathology

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Description

This monoclonal antibody reacts with human and mouse MSH2 (MutS homologue 2), a 100 kDa protein involved in mismatched nucleotides during DNA replication or repair process. It recognizes an epitope within the C-terminal region of the MSH2 protein. MSH2 functions as one of the four major DNA mismatch repair genes, along with MLH1, PMS2 and PMS1. Somatic mutations in the human MSH2 gene contribute to development of sporadic colorectal carcinomas, while germline mutations are involved in a large number of colorectal carcinomas. Positive tissue: Normal colon/breast cancer.

Clone/PAD: FE11

Immunogen: C-terminal fragment of the human MSH2 protein

Specificity: MSH2

Reactivity: Human, Mouse

Applications: Immunohistochemistry (FFPE)

Pretreatment: Epitope Retrieval: Required (EDTA, pH 8.0), Enzyme Digestion: Not Required

Expected Staining Pattern: Predominantly nuclear with some cytoplasmic
For In Vitro Diagnostic Use.

Specifications

Reactivity: Human, Mouse
Validated Application: Immunohistochemistry (FFPE)
Host Species: Mouse
SubClass (Isotype): IgG1, kappa
Clonality: Monoclonal
Target Gene: MSH2
Gene ID: 4436
Label or Dye: Unconjugated
Dilution: Concentrate Antibody
Product Size: 0.2 mL
Shipping Condition: Wet Ice

Contents & storage

Store in refrigerator (2–8°C).

Documents

Manuals & protocols