Multi-Drug Resistance 1 (MDR1) Mouse Monoclonal Antibody (clone C494), Concentrate

Catalog number: 187243

 Related applications: Anatomical Pathology

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Description

This monoclonal antibody reacts with p-glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells with secretory and excretory functions and is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. Elevated levels of p-glycoprotein have been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias/lymphomas. Positive tissue: Liver/colon.

Clone/PAD: C494

Immunogen: Multi-drug resistant CHO cells

Specificity: Reacts with a gene-specific, internal cellular epitope present only on the MDR1 isoform of p-glycoprotein.

Reactivity: Human

Applications: Immunohistochemistry (FFPE)

Pretreatment: Epitope Retrieval: Not required, Enzyme Digestion: Not required

Expected Staining Pattern: Membrane
For In Vitro Diagnostic Use.

Specifications

Reactivity: Human
Validated Application: Immunohistochemistry (FFPE)
Host Species: Mouse
SubClass (Isotype): IgG2a
Clonality: Monoclonal
Target Gene: Multi-Drug Resistance 1 (MDR, p-Glycoprotein)
Gene ID: 4363, 5243, 5244
Label or Dye: Unconjugated
Dilution: Concentrate Antibody
Product Size: 0.5 mL
Shipping Condition: Wet Ice

Contents & storage

Store in refrigerator (2–8°C).

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