Thermo Scientific™

CaptureSelect™ hCG Affinity Matrix

Catalog number: 19434101L
Thermo Scientific™

CaptureSelect™ hCG Affinity Matrix

Catalog number: 19434101L
Catalog Number
19434101L
Unit Size
1 L
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5 mL
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194341050
also known as 1943410050
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50 mL
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Product Overview
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Additional Information
Recommendations
Recommendations
The CaptureSelect™ hCG Affinity Matrix was specifically designed for the purification of human chorionic gonadotropin (hCG) from recombinant sources.

Some features of the CaptureSelect hCG Affinity Matrix include:
• Selective for hCG, with cross-binding to LH, FSH, and TSH
• Enables efficient purification of recombinant gonadotropins with high yields and purity
• Offers excellent scalability
• Non–animal-derived

Human gonadotropins (hCG, LH, FSH, TSH) are glycoprotein hormones secreted by gonadotrope cells of the pituitary gland that are often produced as recombinant proteins. They have an identical alpha chain subunit that is recognized by the ligand. Consequently, the CaptureSelect hCG Affinity Matrix shows binding to all human gonadotropins. The high selectivity and yields obtained using CaptureSelect hCG Affinity Matrix enable a robust and efficient purification process for hCG with excellent purity obtained in one step.

Free of animal components
CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a 12 to 15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in the yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free).

Main characteristics

Matrix: agarose-based, aldehyde-activated
Average particle size: 65 ± 10 µm
Ligand: CaptureSelect hCG affinity ligand
Ligand coupling method: aldehyde coupling via NH2 residues of the ligand
Binding capacity: approx. 4 mg/mL resin (determined with HCG)
Elution conditions: 20 mM citric acid, pH 3.0
Flow characteristics: 50–200 cm/h (up to 2 bar)
Formulation buffer: 20% (v/v) ethanol

Specifications

Shipping Condition
Room Temperature
Particle Size
65 ± 10 micron
Form
Agarose Bead
Column Type
Agarose Resin
Product Line
CaptureSelect™
Type
Affinity Matrix
Stationary Phase
anti-Gonadotropin ligand

Contents & Storage

Store in refrigerator (2–8°C).

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