Thermo Scientific™

Pierce™ Citraconic Anhydride

Catalog number:  20907

 Related applications:

Protein Labeling & Crosslinking

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Thermo Scientific Pierce Citraconic Anhydride reacts with primary amines to to form an amide bond with a terminal carboxyl group. This modification can be reversed using acidic conditions (pH 3-4) or with hydroxylamine.

Citraconic Anhydride (2-methylmaleic anhydride) is used to block primary amine groups at alkaline pH values (pH 7-9). At acidic pH (3-4), the amide linkage is hydrolyzed and citraconic acid is released, revealing the original amine.

Features of Citraconic Anhydride:

• Temporarily block amines to derivatize other parts of the molecule
• Unblock amines using acidic conditions or hydroxylamine
For Research Use Only. Not for use in diagnostic procedures.


Chemical Reactivity: Amine
Label or Dye: Unreactive Group
Product Line: Pierce™
Product Size: 100 g

Contents & storage

Store in a cool, dry area, protected from direct sunlight.


Manuals & protocols