SuperSignal™ West Pico Chemiluminescent Substrate - FAQs

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3 product FAQs found

Can I use SuperSignal West Femto Maximum Sensitivity Substrate with the identical protocol (i.e., same dilutions) I used with the SuperSignal West Pico Chemiluminescent Substrate?

No, these SuperSignal substrates require different dilutions. If you follow the SuperSignal West Pico Chemiluminescent Substrate protocol when you use SuperSignal West Femto Maximum Sensitivity Substrate, you will see high background or a decreased signal intensity and or duration. You must use less (more dilute) primary and secondary antibodies with SuperSignal West Femto Maximum Sensitivity Substrate (see product instructions for recommended ranges).

Find additional tips, troubleshooting help, and resources within our Protein Electrophoresis and Western Blotting Support Center.

Can I use SuperSignal West Dura Extended Duration Substrate with the identical protocol (i.e., same dilutions) I used with the SuperSignal West Pico Chemiluminescent Substrate?

No, these SuperSignal substrates require different dilutions. If you follow the SuperSignal West Pico Chemiluminescent Substrate protocol when you use SuperSignal West Dura Extended Duration Substrate, you will see high background or a decreased signal intensity and or duration. You must use less (more dilute) primary and secondary antibodies with SuperSignal West Dura Extended Duration Substrate (see product instructions for recommended ranges).

Find additional tips, troubleshooting help, and resources within our Protein Assays and Analysis Support Center.

How does SuperSignal West Pico PLUS Chemiluminescent Substrate compare with the original SuperSignal West Pico Chemiluminescent Substrate?

SuperSignal West Pico PLUS Chemiluminescent Substrate has a higher sensitivity and greater forgiveness for broad dilution range compared to SuperSignal West Pico Chemiluminescent Substrate. Please also see Tech Tip # 32 Guide to Enzyme Substrates for Western Blotting (https://tools.thermofisher.com/content/sfs/brochures/TR0032-Substrates-Western.pdf).

Find additional tips, troubleshooting help, and resources within our Protein Electrophoresis and Western Blotting Support Center.