Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase.
AuthorsGao J, Siddoway B, Huang Q, Xia H,
JournalBiochem Biophys Res Commun
PubMed ID19070599
'CREB activation via phosphorylation at serine 133 and resulting CREB mediated gene expression is a critical event which can have a significant effect on many cellular processes, including cell survival and plasticity. CREB can be activated by many kinases, for example, it can be phosphorylated by PKA, MAPK, and CaMKIV. ... More