Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity.
AuthorsWang Y, Rattner A, Zhou Y, Williams J, Smallwood PM, Nathans J,
JournalCell
PubMed ID23217714
Norrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control retinal vascular development. Using genetically engineered mice, we show that precocious Norrin production leads to premature retinal vascular invasion and delayed Norrin production leads to characteristic defects in intraretinal vascular architecture. In genetic mosaics, wild-type endothelial cells (ECs) instruct neighboring ... More