Product References
Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35.
Molecular psychiatry
Li JG,Chiu J,Praticò D
Published figure using PEN2 polyclonal antibody (Product # 36-7100) in Western Blot
Thu Oct 01 00:00:00 EDT 2020
A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Molecular neurodegeneration
Li JG,Chiu J,Ramanjulu M,Blass BE,Praticò D
Published figure using PEN2 polyclonal antibody (Product # 36-7100) in Western Blot
Wed Jan 22 00:00:00 EST 2020
Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy.
Annals of clinical and translational neurology
Lauretti E,Iuliano L,Praticò D
Published figure using PEN2 polyclonal antibody (Product # 36-7100) in Western Blot
Tue Aug 01 00:00:00 EDT 2017
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Scientific reports
Li JG,Barrero C,Merali S,Praticò D
367100 was used in western blot to show that ALOX5 upregulation results in homocysteine-dependent worsening of the Alzheimer's disease phenotype
Thu Apr 06 00:00:00 EDT 2017
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Scientific reports
Li JG,Barrero C,Merali S,Praticò D
367100 was used in western blot to show that ALOX5 upregulation results in homocysteine-dependent worsening of the Alzheimer's disease phenotype
Thu Apr 06 00:00:00 EDT 2017
Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer's disease.
Scientific reports
Lauretti E,Praticò D
Published figure using PEN2 polyclonal antibody (Product # 36-7100) in Western Blot
Thu Dec 07 00:00:00 EST 2017
Sodium Chloride Increases Aβ Levels by Suppressing Aβ Clearance in Cultured Cells.
PloS one
Cheng XJ,Gao Y,Zhao YW,Cheng XD
Published figure using PEN2 polyclonal antibody (Product # 36-7100) in Western Blot
Wed May 04 00:00:00 EDT 2016
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.
Nature communications
Wang J,Lu R,Yang J,Li H,He Z,Jing N,Wang X,Wang Y
36-7100 was used in western blot to characterize the interaction of TRPC6 with APP to inhibit its cleavage by gamma-secretase and reduce A-beta production
Thu Nov 19 00:00:00 EST 2015
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.
Annals of neurology
Li JG,Chu J,Barrero C,Merali S,Praticò D
Published figure using PEN2 polyclonal antibody (Product # 36-7100) in Western Blot
Sun Jun 01 00:00:00 EDT 2014
Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Watanabe H,Iqbal M,Zheng J,Wines-Samuelson M,Shen J
36-7100 was used in western blot to assess the effects of presenilin dosage on cortical neuron survival in mice.
Wed Nov 26 00:00:00 EST 2014
Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Heilig EA,Gutti U,Tai T,Shen J,Kelleher RJ
Wed Jul 10 00:00:00 EDT 2013
Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Heilig EA,Gutti U,Tai T,Shen J,Kelleher RJ
Wed Jul 10 00:00:00 EDT 2013
Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Watanabe H,Xia D,Kanekiyo T,Kelleher RJ,Shen J
36-7100 was used in western blot to study the effects of a familial frontotemporal dementia-associated presenilin- c.548G>T mutation in knock-in mice.
Wed Apr 11 00:00:00 EDT 2012
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
The Journal of biological chemistry
Matsushima T,Saito Y,Elliott JI,Iijima-Ando K,Nishimura M,Kimura N,Hata S,Yamamoto T,Nakaya T,Suzuki T
Fri Jun 01 00:00:00 EDT 2012
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
Annals of neurology
Chu J,Praticò D
Sat Jan 01 00:00:00 EST 2011
Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence.
PloS one
Puccio S,Chu J,Praticò D
Thu Jan 06 00:00:00 EST 2011
Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB.
Molecular and cellular biology
Wang R,Zhang YW,Sun P,Liu R,Zhang X,Zhang X,Xia K,Xia J,Xu H,Zhang Z
Wed Feb 01 00:00:00 EST 2006
Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB.
Molecular and cellular biology
Wang R,Zhang YW,Sun P,Liu R,Zhang X,Zhang X,Xia K,Xia J,Xu H,Zhang Z
Wed Feb 01 00:00:00 EST 2006