The oncogenic TBX3 is a downstream target and mediator of the TGF-ß1 signaling pathway.
AuthorsLi J, Weinberg MS, Zerbini L, Prince S,
Journal
PubMed ID24025717
'The T-box transcription factor, TBX3, plays an important role in embryonic development, and haploinsufficiency of TBX3 causes ulnar-mammary syndrome. Overexpression of TBX3, on the other hand, is associated with several cancers, and preliminary evidence suggests that increased levels of TBX3 may inhibit cell proliferation but promote tumor migration and invasion. ... More
Basal transcription of the human TBX3 gene, a key developmental regulator which is overexpressed in several cancers, requires functional NF-Y and Sp1 sites.
AuthorsSmith J, Mowla S, Prince S,
JournalGene
PubMed ID21784138
'TBX3 is a member of the T-box family of genes that encode developmentally important transcription factors. Mutations resulting in decreased levels of functional TBX3 lead to Ulnar-Mammary Syndrome and increased levels of TBX3 have been linked to several cancers. To understand the mechanisms regulating TBX3 expression we have previously cloned ... More