AutoMate Express™ Nucleic Acid Extraction System

Catalog number: 4467754

Applied Biosystems™  Related applications: Contaminant & Impurity QC Testing

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Description

The AutoMate Express™ Nucleic Acid Extraction System is an easy-to-use benchtop instrument that enables hands-free automation of the nucleic acid extraction process for contaminant and impurity testing. The instrument uses the established PrepSEQ® nucleic acid extraction chemistry for quantitative recovery of DNA and RNA from diverse samples types, including cell culture, raw material (i.e., serum), and in-process downstream purification samples such as column purification or bulk drug substance (BDS) samples.

Key Product Features:

• Time-saving, cost-effective DNA extraction for mycoplasma, MMV, vesivirus, and residual DNA quantitation
• Quantitative and reproducible recovery of DNA from complex samples
• Out-of-the-box automation with prefilled PrepSEQ® Express™ cartridges and ready-to-run protocols
• Closed system minimizes the risk of contamination
• Ideal for in-process testing of contaminants and impurities

Three-in-One Extraction of Cell Culture Contaminants
The AutoMate Express™ system can be used to perform nucleic acid extraction of the common contaminants for mammalian cell culture manufacturing, i.e., mycoplasmas, MMV, and vesiviruses (Figure 1). Flexible protocols are available to isolate DNA and RNA from a single organism, or a 3-in-1 surveillance panel protocol can simultaneously extract mycoplasma, MMV, and vesivirus nucleic acid from a single sample.

Quantitative Recovery for Residual DNA Applications
The AutoMate Express™ system is also designed for highly efficient recovery of host cell residual DNA from complex samples typically recovered during biopharmaceutical purification processes. The system facilitates quantitative and consistent recovery of DNA from challenging matrices, including samples that have high protein concentration, low pH, or high salt (Figure 2).

Closed System with Walk-Away Automation
The AutoMate Express™ system automatically performs all steps for efficient nucleic acid extraction from contaminants and impurities in a closed environment. The system uses PrepSEQ® Express™ kits that contain sealed cartridges with extraction reagents, and plastics, including tips and sample, lysis, and elution tubes. The workflow has been designed for a completely hands-free operation enabling reproducible extraction efficiencies and reduced time-to-results.

For Research Use Only. Not for use in diagnostic procedures.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Format: Cartridge
Capacity: Up to 13 samples per run
Product Size: 1 instrument
Purification Time: ≤ 1 hr
Isolation Technology: Magnetic Bead
Sample Type (General): Biopharmaceutical Production Samples
For Use With (Equipment): AutoMate Express™ Nucleic Acid Extraction System
High Throughput Compatibility: Automated Protocols

Contents & storage

Store at room temperature.

Documents

Manuals & protocols

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