Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.
AuthorsYamaguchi T, Sharma P, Athanasiou M, Kumar A, Yamada S, Kuehn MR,
JournalMol Cell Biol
PubMed ID15923632
'The covalent modification of proteins by the small ubiquitin-like protein SUMO has been implicated in the regulation of numerous biological processes, including nucleocytoplasmic transport, genomic stability, and gene transcription. Sumoylation occurs by a multienzyme process similar to ubiquitination and, in Saccharomyces cerevisiae, is reversed by desumoylating enzymes encoded by the ... More
Positive and negative regulation of APP amyloidogenesis by sumoylation.
AuthorsLi Y, Wang H, Wang S, Quon D, Liu YW, Cordell B,
JournalProc Natl Acad Sci U S A
PubMed ID12506199
'Amyloid beta peptide (Abeta) generated from amyloid precursor protein (APP) is central to Alzheimer''s disease (AD). Signaling pathways affecting APP amyloidogenesis play critical roles in AD pathogenesis and can be exploited for therapeutic intervention. Here, we show that sumoylation, covalent modification of cellular proteins by small ubiquitin-like modifier (SUMO) proteins, ... More
Regulation of vaccinia virus E3 protein by small ubiquitin-like modifier proteins.
AuthorsGonzález-Santamaría J, Campagna M, García MA, Marcos-Villar L, González D, Gallego P, Lopitz-Otsoa F, Guerra S, Rodríguez MS, Esteban M, Rivas C
JournalJ Virol
PubMed ID21957283
The vaccinia virus (VACV) E3 protein is essential for virulence and has antiapoptotic activity and the ability to impair the host innate immune response. Here we demonstrate that E3 interacts with SUMO1 through a small ubiquitin-like modifier (SUMO)-interacting motif (SIM). SIM integrity is required for maintaining the stability of the ... More
Inhibition of DNA binding by differential sumoylation of heat shock factors.
Covalent modification of proteins by the small ubiquitin-related modifier SUMO regulates diverse biological functions. Sumoylation usually requires a consensus tetrapeptide, through which the binding of the SUMO-conjugating enzyme Ubc9 to the target protein is directed. However, additional specificity determinants are in many cases required. To gain insights into SUMO substrate ... More
Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life.
AuthorsWong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H,
JournalMol Cell Biol
PubMed ID15169916
Protein inhibitor of activated STAT Y (PIASy) is the shortest member of the PIAS family and has been reported to modulate the transcriptional activities of STAT1, lymphoid enhancer factor 1 (LEF-1), and the androgen receptor. PIAS proteins have also been identified as E3 ligases for the small ubiquitin-like modifier (SUMO) ... More