Thermo Scientific™

POROS™ XS Strong Cation Exchange Resin

Catalog number: 82071
Thermo Scientific™

POROS™ XS Strong Cation Exchange Resin

Catalog number: 82071
Catalog Number
82071
Unit Size
10 mL
Price (USD)
Availability
-
Quantity
Catalog Number
Unit Size
50 mL
Price (USD)
Availability
-
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
8207110 mL
-
8207250 mL
-
Product Overview
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POROS™ XS Strong Cation Exchange Resin is the first high-capacity, high-resolution resin that allows loading to more than 100 mg/mL capacity in the presence of up to 15 mS/cm NaCl, while delivering unprecedented separation capability. A major improvement on traditional cation exchangers, POROS XS resin sets the standard for cation exchange chromatography.

• Dynamic binding capacity leads to reduced column size, smaller footprint, decreased buffer usage, and reduced cycling
• High resolution supports better product yield and improved impurity clearance
• Robust salt tolerance allows improved process flexibility, alignment, and process flow streamlining
• Low back pressure and linear pressure responses help improve scalability
• Rigid polymeric bead with covalent surface chemistry makes for easier handling and packing, and superior physical and chemical stability, resulting in a robust manufacturing process

Dynamic binding capacity
POROS XS resin has a high binding capacity of more than 100 mg/mL, at 5% breakthrough, over a broad range of process conditions.Higher dynamic binding capacity was achieved by optimizing the base bead pore structure and surface chemistry.

High resolution
Using an optimized 50 μm particle size, POROS XS resin maintains the superior resolving capacity of POROS™ HS resin while overcoming the challenging impurity levels associated with high titer processes. Resolution is consistent across a wide range of operating flow rates and is maintained independent of protein load.

Robust salt tolerance
POROS XS resin has high and consistent protein capacity across a broad range of salt concentrations up to 150 mM NaCl (15 mS/cm conductivity). The ability to load columns under higher conductivity reduces or helps eliminate the dilution of column feed streams or the removal of unit operations, such as tangential flow filtration. The optimized surface ionic capacity of POROS XS resin minimizes competitive binding between the protein of interest and the counterion, resulting in superior salt tolerance.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Format
Poros Bead
Product Line
POROS™
Purification Target
Protein
Shipping Condition
Room Temperature
Stationary Phase
XS
Type
XS Strong Cation Exchange Resin
Standard Components
Crosslinked Poly(styrene-divinylbenzene)
For Use With (Application)
Cation Exchange Chromatography
Volume (Metric)
10 mL

Contents & Storage

Store in refrigerator (2–8°C).

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