Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release.
AuthorsYoshikawa Y, Hirayasu H, Tsuzuki S, Fushiki T
JournalBiosci Biotechnol Biochem
PubMed ID18776661
'Granzyme A (GrA) is a serine protease produced in cytotoxic lymphocytes, lung epithelial cells (alveolar type-II cells), and alveolar macrophages. In the present study, recombinant rat GrA (rGrA) was found to cause rounding and detachment of an alveolar type-II epithelial cell line, A549. Also, rGrA stimulated release of a neutrophil ... More