The molecular and functional basis of allergen-induced inflammation seen in atopic dermatitis (AD) remains undefined.
Versican/PG-M is essential for ventricular septal formation subsequent to cardiac atrioventricular cushion development.
AuthorsHatano S, Kimata K, Hiraiwa N, Kusakabe M, Isogai Z, Adachi E, Shinomura T, Watanabe H
JournalGlycobiology
PubMed ID22692047
Versican (Vcan)/proteoglycan (PG)-M is a large chondroitin sulfate proteoglycan which forms a proteoglycan/hyaluronan (HA) aggregate in the extracellular matrix (ECM). We tried to generate the Vcan knockout mice by a conventional method, which resulted in mutant mice Vcan(?3/?3) whose Vcan lacks the A subdomain of the G1 domain. The Vcan ... More