4-Methylumbelliferone, 97%
4-Methylumbelliferone, 97%
4-Methylumbelliferone, 97%
4-Methylumbelliferone, 97%
Thermo Scientific Chemicals

4-Methylumbelliferone, 97%

CAS: 90-33-5 | C10H8O3 | 176.17 g/mol
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Catalog number A10337.30
also known as A10337-30
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Chemical Identifiers
CAS90-33-5
IUPAC Name7-hydroxy-4-methyl-2H-chromen-2-one
Molecular FormulaC10H8O3
InChI KeyHSHNITRMYYLLCV-UHFFFAOYSA-N
SMILESCC1=CC(=O)OC2=CC(O)=CC=C12
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to cream to pale yellow to pale brown
Assay (Aqueous acid-base Titration)≥96.0 to ≤104.0%
Assay (HPLC)≥96.0%
Melting Point (clear melt)184.0-194.0?C
Identification (FTIR)Conforms
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4-Methylumbelliferone is used in the determination of nitric acid and as a standard for fluorometric determination of enzyme activity. It is also used in bile therapy.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Methylumbelliferone is used in the determination of nitric acid and as a standard for fluorometric determination of enzyme activity. It is also used in bile therapy.

Solubility
Soluble in alcohol. Insoluble in cold water. Soluble in acetic acid, alkali and ammonium hydroxide. Slightly soluble in hot water, chloroform and diethyl ether.

Notes
Store in a cool place. Incompatible with strong bases and strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Standard for fluorimetric determination of enzyme activity: Anal. Biochem., 54, 40; 55, 85 (1973).
  2. Franco, P. G.; Perez, M. J.; Aranda, C.; Adamo, A.; Silvestroff, L. Improving arylsulfatase activity determination in dried blood spots: Screening and diagnostic approaches for Maroteaux-Lamy syndrome (MPS VI). Clin. Chim. Acta 2015, 446, 86-92.
  3. Kłucinska, K.; Jurczakowski, R.; Maksymiuk, K.; Michalska, A. Ultrasensitive 4-methylumbelliferone fluorimetric determination of water contents in aprotic solvents. Talanta 2015, 132, 392-397.