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1-Methylpiperazine, 98+%
1-Methylpiperazine, 98+%
1-Methylpiperazine, 98+%
Thermo Scientific Chemicals

1-Methylpiperazine, 98+%

CAS: 109-01-3 | C5H12N2 | 100.165 g/mol
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Catalog number A10837.AE
also known as A10837-AE
Price (USD)
32.65
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Ends: 30-Jun-2026
38.40
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Quantity:
100 mL
Request bulk or custom format
Price (USD)
32.65
Special offer
Online exclusive
Ends: 30-Jun-2026
38.40
Save 5.75 (15%)
Each
Chemical Identifiers
CAS109-01-3
IUPAC Name1-methylpiperazine
Molecular FormulaC5H12N2
InChI KeyPVOAHINGSUIXLS-UHFFFAOYSA-N
SMILESCN1CCNCC1
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SpecificationsSpecification SheetSpecification Sheet
FormLiquid
Assay (GC)≥98.0%
Identification (FTIR)Conforms
Refractive Index1.4635-1.4675 @ 20?C
Appearance (Color)Clear colorless to pale yellow
1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Solubility
Miscible with water and methanol.

Notes
Hygroscopic. Moisture sensitive. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents and carbon dioxide.
RUO – Research Use Only

General References:

  1. For preparation of a reagent for the high-yield reduction of esters to aldehydes, see Sodium bis(2-methoxyethoxy) aluminum hydride, A13292. Similarly, addition of the hydrochloride to Lithium aluminum hydride, A18116, gives a complex which can reduce carboxylic acids to aldehydes: J. Org. Chem., 49, 2279 (1984).
  2. The N-lithio-derivative effects the O-alkyl cleavage of aromatic ortho-alkoxyaldehydes or ketones, without the need for carbonyl protection: Synth. Commun., 18, 191 (1988).
  3. Li, H.; Le Moullec, Y.; Lu, J.; Chen, J.; Marcos, J. C. V.; Chen, G.; Chopin, F. CO2 solubility measurement and thermodynamic modeling for 1-methylpiperazine/water/CO2. Fluid Phase Equilib. 2015, 394, 118-128.
  4. Kovalev, V. V.; Gorbunova, Y. E.; Kokunov, Y. V. Silver nitrate coordination polymer with 1-methylpiperazine: Synthesis and crystal structure. Russ. J. Inorg. Chem. 2015, 60 (7), 886-888.