Diisopropyl methylphosphonate is used as a precursor to prepare beta-keto phosphonates. It acts as an intermediate for Horner-Wadsworth-Emmons olefination of carbonyl compounds.
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Applications
Diisopropyl methylphosphonate is used as a precursor to prepare beta-keto phosphonates. It acts as an intermediate for Horner-Wadsworth-Emmons olefination of carbonyl compounds.
Solubility
Miscible with water.
Notes
Store in cool place. Incompatible with acids, oxidizing agents, alkali metals, strong oxidizing agents, strong acids, acid chlorides, acid anhydrides, reducing agents, strong reducing agents and phosphorus halides.
RUO – Research Use Only
General References:
- Reacts with esters giving ß-keto phosphonates, useful intermediates for Horner-Wadsworth-Emmons olefination of carbonyl compounds, cf Dimethyl methyl phosphonate, A14268.
- Terzic, O.; Gregg, H.; Voogt, P. Identification of chemicals relevant to the Chemical Weapons Convention using the novel sample-preparation methods and strategies of the Mobile Laboratory of the Organization for the Prohibition of Chemical Weapons. TrAC, Trends Anal. Chem. 2015, 65, 151-166.
- Maza, W. A.; Vetromile, C. M.; Kim, C.; Xu, X.; Zhang, X. P.; Larsen, R. W. Spectroscopic Investigation of the Noncovalent Association of the Nerve Agent Simulant Diisopropyl Methylphosphonate (DIMP) with Zinc(II) Porphyrins. J. Phys. Chem. A 2013, 117 (44), 11308-11315.