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Thermo Scientific Chemicals
5-Fluorouracil, 99%
CAS: 51-21-8 | C4H3FN2O2 | 130.08 g/mol
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Catalog number A13456.22
also known as A13456-22
Price (USD)
1,175.65
Online Exclusive
1,306.00Save 130.35 (10%)
Each
Quantity:
100 g
Price (USD)
1,175.65
Online Exclusive
1,306.00Save 130.35 (10%)
Each
Chemical Identifiers
CAS51-21-8
IUPAC Name5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
Molecular FormulaC4H3FN2O2
InChI KeyGHASVSINZRGABV-UHFFFAOYSA-N
SMILESFC1=CNC(=O)NC1=O
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Specifications
Specification Sheet
Specification SheetFormCrystalline powder
Appearance (Color)White to pale cream
Assay from Suppliers CofA≥98.5%
5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.
Notes
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.
Notes
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only
General References:
- Antineoplastic agent. Not for drug use.
- Cosco, D.; Paolino, D.; Maiuolo, J.; Di Marzio, L.; Carafa, M.; Ventura, C. A.; Fresta, M. Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery. Int. J. Pharm. 2015, 489 (1-2), 1-10.
- Wu, X.; He, C.; Wu, Y.; Chen, X. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials 2016, 75, 148-162.