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1,1,1-Trifluoroacetone, 95%
CAS: 421-50-1 | C3H3F3O | 112.051 g/mol
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Catalog number A13556.14
also known as A13556-14
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Quantity:
25 g
Price (USD)
117.65
Online Exclusive
130.00Save 12.35 (10%)
Each
Chemical Identifiers
CAS421-50-1
IUPAC Name1,1,1-trifluoropropan-2-one
Molecular FormulaC3H3F3O
InChI KeyFHUDAMLDXFJHJE-UHFFFAOYSA-N
SMILESCC(=O)C(F)(F)F
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Specifications
Specification Sheet
Specification SheetAppearance (Color)Clear colorless to pale yellow to yellow to orange
Assay (GC)≥94.0%
Refractive Index<1.3000 @ 20?C
Identification (FTIR)Conforms
FormLiquid
1,1,1-Trifluoroacetone is used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction. And also used as a useful molecule in synthesis reactions.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1,1,1-Trifluoroacetone is used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction. And also used as a useful molecule in synthesis reactions.
Solubility
Insoluble in water.
Notes
Air Sensitive. Store in cool, dry conditions in well sealed containers. Keep container tightly closed.
1,1,1-Trifluoroacetone is used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction. And also used as a useful molecule in synthesis reactions.
Solubility
Insoluble in water.
Notes
Air Sensitive. Store in cool, dry conditions in well sealed containers. Keep container tightly closed.
RUO – Research Use Only
General References:
- Gandini, A.; Hackett, P.A. Electronic relaxation processes in acetone and 1,1,1-trifluoroacetone vapor and the gas phase recombination of the acetyl radical at 22.degree.C. J. Am. Chem. Soc. 1977, 99, (19), 6195-6205.
- Jonathan O. Smith.; Braja K. Mandal.; Robert Filler.; James W. Beery. Reaction of ethyl 4,4,4-trifluoroacetoacetate enolate with 3-bromo-1,1,1-trifluoroacetone: synthesis of 2,4-bis (trifluoromethyl) furan. Journal of Fluorine Chemistry. 1977, 81, (2), 123-128.