It is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone. It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
It is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone. It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids).
Solubility
Insoluble in water.
Notes
Light sensitive. Store in a cool, dry, well-ventilated area. Store away from oxidizing agent, light.
RUO – Research Use Only
General References:
- Shenlin Huang; James M. Tour. Rapid bi-directional synthesis of oligo(1, 4-phenylene ethynylene)s. Tetrahedron Letters. 1999, 40 (17), 3447-3450.
- Harry A.J. Oonk; Peter R. van der Linde; Jan Huinink; Jacobus G. Blok. Representation and assessment of vapour pressure data; a novel approach applied to crystalline 1-bromo-4-chlorobenzene, 1-chloro-4-iodobenzene, and 1-bromo-4-iodobenzene. J. Chem. Thermodyn. 1998, 30 (7), 897-907.