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(Chloromethyl)trimethylsilane, 98%
CAS: 2344-80-1 | C4H11ClSi | 122.667 g/mol
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Catalog number A14303.09
also known as A14303-09
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10 g
Price (USD)
52.65
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58.80Save 6.15 (10%)
Each
Chemical Identifiers
CAS2344-80-1
IUPAC Name(chloromethyl)trimethylsilane
Molecular FormulaC4H11ClSi
InChI KeyOOCUOKHIVGWCTJ-UHFFFAOYSA-N
SMILESC[Si](C)(C)CCl
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Specifications
Specification Sheet
Specification SheetIdentification (FTIR)Conforms
Appearance (Color)Clear colorless
FormLiquid
Refractive Index1.4155-1.4195 @ 20?C
Assay (GC)≥97.5%
(Chloromethyl)trimethylsilane is used for Wittig reaction and building blocks.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
(Chloromethyl)trimethylsilane is used for Wittig reaction and building blocks.
Solubility
Soluble in water (0.4g/L at 20°C).
Notes
Store in cool, well ventilated area. Keep container tightly closed. Moisture sensitive. Store under argon.
(Chloromethyl)trimethylsilane is used for Wittig reaction and building blocks.
Solubility
Soluble in water (0.4g/L at 20°C).
Notes
Store in cool, well ventilated area. Keep container tightly closed. Moisture sensitive. Store under argon.
RUO – Research Use Only
General References:
- Akira Sekiguchi; Wataru Ando. Direct synthesis of terminal olefins from ketones. Application of (chloromethyl)trimethylsilane to a Wittig reaction. J. Org. Chem. 1979, 44 (3), 413-415.
- John W. Connolly; Grant Urry. The Wurtz Reaction of Chloromethyltrimethylsilane. A Classical Study. J. Org. Chem. 1964, 29 (3), 619-623.
- Treatment with s-BuLi at -78° gives ɑ-lithio-ɑ-chloromethyltrimethylsilane which reacts with aldehydes and ketones to give ɑß-epoxy silanes, readily hydrolyzed to homologated aldehydes: Tetrahedron, 39, 867 (1983):
- Metallation gives useful precursors of various organosilicon compounds. For use of the Grignard in the olefination of ketones, see: J. Org. Chem., 39, 3264 (1974); 52, 281 (1987). For Ni-catalyzed reaction of the Grignard with allylic dithioacetals, see: J. Org. Chem., 53, 5582 (1988); Org. Synth. Coll., 9, 727 (1998); for an example with reaction scheme, see trans-Cinnamaldehyde, A14689.
- For a review of the chemistry of chloromethyltrimethylsilane, see: Synthesis, 717 (1985).