6-Aminohexanoic acid, 99%
6-Aminohexanoic acid, 99%
6-Aminohexanoic acid, 99%
6-Aminohexanoic acid, 99%
Thermo Scientific Chemicals

6-Aminohexanoic acid, 99%

6-aminohexanoic acid, CAS # 60-32-2, is a synthetic lysine derivative with inhibitory activity against fibrinolysis. It shows hematologic activity. | CAS: 60-32-2 | C6H13NO2 | 131.175 g/mol
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Catalog number A14719.22
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Chemical Identifiers
CAS60-32-2
IUPAC Name6-aminohexanoic acid
Molecular FormulaC6H13NO2
InChI KeySLXKOJJOQWFEFD-UHFFFAOYSA-N
SMILESNCCCCCC(O)=O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White
FormCrystalline powder
Assay (Non-aqueous acid-base Titration)≥98.5% to ≤101.5%
Identification (FTIR)Conforms
Melting Pointca. 200-210?C dec.
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6-Aminohexanoic acid is used as an intermediate in the polymerization of Nylon-6. It is involved in the extraction of aldehydes from the reaction mixture as well as to improve the solubilization of membrane proteins in electrophoresis. It acts as an inhibitor of fibrinolysis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • 6-aminohexanoic acid, an epsilon-amino acid, shows an antifibrinolytic and hematologic activity
  • This compound competitively inhibits the activation of plasminogen; it consequently reduces the conversion of plasminogen to plasmin (fibrinolysin), an enzyme responsible for the degradation of fibrin clots, fibrinogen, and other plasma proteins, including the procoagulant factors V and VIII

Application

  • It has been used as an intermediate in the polymerization of Nylon-6
  • It is used for biomolecular applications to extract aldehydes from the reaction mixture and to increase membrane protein solubilization in electrophoresis experiments
  • It has been described to inhibit plasminogen binding to activated platelets
  • This compound can bind and inactivate carboxypeptidase B
  • This compound can also inhibit the activation of the first component of the complement system
RUO – Research Use Only

General References:

  1. Has been recommended as a reagent for the extraction of aldehydes from reaction mixtures, giving better recovery than bisulfite: Chem. Pharm. Bull., 28, 1917 (1980).
  2. Gamez, L. M.; Franco, L.; Casas, M. T.; Puiggali, J. Crystallization studies on a clay nanocomposite prepared from a degradable poly(ester amide) constituted by glycolic acid and 6-aminohexanoic acid. Polym. Eng. Sci. 2011, 51 (8), 1650-1661.
  3. Sattler, J. H.; Fuchs, M.; Mutti, F. G.; Grischek, B.; Engel, P.; Pfeffer, J.; Woodley, J. M.; Kroutil, W. Introducing an In Situ Capping Strategy in Systems Biocatalysis To Access 6-Aminohexanoic acid. Angew. Chem. 2014, 126 (51), 14377-14381.