2,4-Dichloropyrimidine, 98+%
2,4-Dichloropyrimidine, 98+%
2,4-Dichloropyrimidine, 98+%
Thermo Scientific Chemicals

2,4-Dichloropyrimidine, 98+%

CAS: 3934-20-1 | C4H2Cl2N2 | 148.974 g/mol
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Catalog number A15131.06
also known as A15131-06
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Chemical Identifiers
CAS3934-20-1
IUPAC Name2,4-dichloropyrimidine
Molecular FormulaC4H2Cl2N2
InChI KeyBTTNYQZNBZNDOR-UHFFFAOYSA-N
SMILESClC1=CC=NC(Cl)=N1
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to yellow
FormCrystals or crystalline powder and/or chunks
Assay (GC)≥98.0%
Identification (FTIR)Conforms
Melting Point (clear melt)57-62?C
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2,4-Dichloropyrimidine is used in the synthesis of medicinally important 4-aryl-5-pyrimidinylimidazoles. It undergoes effective one-pot, regioselective double Suzuki coupling reaction to yield diarylated pyrimidines.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2,4-Dichloropyrimidine is used in the synthesis of medicinally important 4-aryl-5-pyrimidinylimidazoles. It undergoes effective one-pot, regioselective double Suzuki coupling reaction to yield diarylated pyrimidines.

Solubility
Soluble in water (partly), methanol, chloroform, and ethyl acetate.

Notes
Moisture Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only

General References:

  1. Xiaohu Deng.; Neelakandha S. Mani. An Efficient Route to 4-Aryl-5-pyrimidinylimidazoles via Sequential Functionalization of 2,4-Dichloropyrimidine. Org. Lett. 2006, 8, (2), 269-272.
  2. Zhi-Hui Peng.; Michel Journet.; Guy Humphrey. A Highly Regioselective Amination of 6-Aryl-2,4-dichloropyrimidine. Org. Lett. 2006, 8, (3), 395-398.