Cardiac disease modeling using induced pluripotent stem cell-derived human cardiomyocytes.
AuthorsDell'Era P, Benzoni P, Crescini E, Valle M, Xia E, Consiglio A, Memo M,
Journal
PubMed ID25815118
Causative mutations and variants associated with cardiac diseases have been found in genes encoding cardiac ion channels, accessory proteins, cytoskeletal components, junctional proteins, and signaling molecules. In most cases the functional evaluation of the genetic alteration has been carried out by expressing the mutated proteins in in-vitro heterologous systems. While ... More